Mingyang Wu1, Yanling Shu2, Lulu Song1, Bingqing Liu1, Lina Zhang1, Lulin Wang1, Yunyun Liu1, Jianing Bi1, Chao Xiong3, Zhongqiang Cao4, Shunqing Xu5, Wei Xia5, Yuanyuan Li5, Youjie Wang6. 1. Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. 2. Department of Nutrition and Food Hygiene, School of Public Health, Guangdong Medical University, Dongguan, Guangdong, China. 3. Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. 4. Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: bestfriends985@163.com. 5. Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. 6. Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: wangyoujie@mails.tjmu.edu.cn.
Abstract
BACKGROUND: Prenatal exposure to thallium is related to adverse birth outcomes. However, little is known about the effects of prenatal exposure to thallium on the mitochondrial DNA copy number (mtDNAcn) in newborns; such knowledge might reveal a potential mechanism linking maternal thallium exposure and adverse birth outcomes. OBJECTIVE: To investigate the trimester-specific associations of maternal thallium exposure with cord blood leukocyte mtDNAcn. METHODS: A total of 746 pregnant women with trimester-specific urinary samples and cord blood samples were recruited from Wuhan Children Hospital between November 2013 and March 2015 in Wuhan City, China. The concentration of thallium in maternal urine was quantified using inductively coupled plasma mass spectrometry (ICP-MS). Cord blood leukocyte mtDNAcn was measured by real-time quantitative polymerase chain reaction (qPCR). Trimester-specific associations of specific gravity (SG)-adjusted urinary thallium concentrations with mtDNAcn were estimated using a multiple informant model. RESULTS: The geometric mean value of maternal urinary thallium was 0.34 μg/L, 0.36 μg/L, and 0.34 μg/L for the first, second, and third trimesters, respectively. Prenatal exposure to thallium during the first trimester, rather than during the second or the third trimester, was identified as negatively related to mtDNAcn. The multiple informant model showed a 10.4% lower level of mtDNAcn with each doubling increase of thallium levels (95% CI, -16.4%, -3.9%; P = 0.002). The observed associations were stronger among female newborns and among newborns born to older mothers. CONCLUSIONS: The present study revealed a significant negative association between maternal thallium exposure during early pregnancy and cord blood leukocyte mtDNAcn in Chinese newborns, pointing to the important role of mitochondria as a target of thallium toxicity in early pregnancy.
BACKGROUND: Prenatal exposure to thallium is related to adverse birth outcomes. However, little is known about the effects of prenatal exposure to thallium on the mitochondrial DNA copy number (mtDNAcn) in newborns; such knowledge might reveal a potential mechanism linking maternal thallium exposure and adverse birth outcomes. OBJECTIVE: To investigate the trimester-specific associations of maternal thallium exposure with cord blood leukocyte mtDNAcn. METHODS: A total of 746 pregnant women with trimester-specific urinary samples and cord blood samples were recruited from Wuhan Children Hospital between November 2013 and March 2015 in Wuhan City, China. The concentration of thallium in maternal urine was quantified using inductively coupled plasma mass spectrometry (ICP-MS). Cord blood leukocyte mtDNAcn was measured by real-time quantitative polymerase chain reaction (qPCR). Trimester-specific associations of specific gravity (SG)-adjusted urinary thallium concentrations with mtDNAcn were estimated using a multiple informant model. RESULTS: The geometric mean value of maternal urinary thallium was 0.34 μg/L, 0.36 μg/L, and 0.34 μg/L for the first, second, and third trimesters, respectively. Prenatal exposure to thallium during the first trimester, rather than during the second or the third trimester, was identified as negatively related to mtDNAcn. The multiple informant model showed a 10.4% lower level of mtDNAcn with each doubling increase of thallium levels (95% CI, -16.4%, -3.9%; P = 0.002). The observed associations were stronger among female newborns and among newborns born to older mothers. CONCLUSIONS: The present study revealed a significant negative association between maternal thallium exposure during early pregnancy and cord blood leukocyte mtDNAcn in Chinese newborns, pointing to the important role of mitochondria as a target of thalliumtoxicity in early pregnancy.
Authors: Jonatan A Mendoza-Ortega; Enrique Reyes-Muñoz; Sonia Nava-Salazar; Sandra Rodríguez-Martínez; Sandra B Parra-Hernández; Lourdes Schnaas; Blanca Vianey Suárez-Rico; Libni A Torres-Olascoaga; Andrea A Baccarelli; Rosalind J Wright; Robert O Wright; Guadalupe Estrada-Gutierrez; Marcela Tamayo-Ortiz Journal: Int J Environ Res Public Health Date: 2021-11-10 Impact factor: 3.390
Authors: Beatrice Campanella; Laura Colombaioni; Edoardo Benedetti; Agostino Di Ciaula; Lisa Ghezzi; Massimo Onor; Massimo D'Orazio; Roberto Giannecchini; Riccardo Petrini; Emilia Bramanti Journal: Int J Environ Res Public Health Date: 2019-11-27 Impact factor: 3.390