Isabel Pinilla1,2, Miriam Idoipe3, Lorena Perdices1,4, Ana Sanchez-Cano1,5, Javier Acha1,6, Maria Isabel Lopez-Galvez7, Nicolas Cuenca8, Emilio Abecia1,3, Elvira Orduna-Hospital1,3. 1. Aragon Institute for Health Research (IIS Aragon), Zaragoza, Spain. 2. Department of Ophthalmology, Lozano Blesa University Hospital, Zaragoza, Spain. 3. Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain. 4. IACS, Zaragoza, Spain. 5. Department of Applied Physics, University of Zaragoza, Zaragoza, Spain. 6. Department of Endocrinology, Miguel Servet University Hospital, Zaragoza, Spain. 7. Department of Ophthalmology, University Hospital, Valladolid, Spain; and. 8. Department of Physiology, Genetics and Microbiology, University of Alicante, Alicante, Spain.
Abstract
PURPOSE: To evaluate changes in retinal layer thickness in patients with Type 1 diabetes with no diabetic retinopathy after 8 years of follow-up. METHODS: Ninety Type 1 diabetes and 60 control eyes were studied. Changes in the retinal nerve fiber layer, ganglion cell layer, and inner nuclear layer thicknesses in all Early Treatment Diabetic Retinopathy Study areas were evaluated. RESULTS: The mean ages were 42.93 ± 13.62 and 41.52 ± 13.05 years in the diabetic and control group, respectively. In 2009, total retinal thickness was higher in diabetic patients; differences were statistically significant in all except the nasal areas. In both groups, the mean foveal thickness remained the same during the 8 years. Among diabetic patients, there was a significant reduction in total retinal thickness in all areas excluding the outer temporal one; controls only in the inferior areas. The thickness loss was due to the thinning of the inner retinal layers (inner nuclear layer, ganglion cell layer, and retinal nerve fiber layer). The controls showed a significant diminution in the retinal nerve fiber layer and in the ganglion cell layer areas. The inner nuclear layer showed a diminution in the diabetes mellitus group. CONCLUSION: Before the onset of diabetic retinopathy, Type 1 diabetes patients experience a diminution of their inner retinal layer thicknesses over time, supporting the hypothesis of retinal neurodegeneration.
PURPOSE: To evaluate changes in retinal layer thickness in patients with Type 1 diabetes with no diabetic retinopathy after 8 years of follow-up. METHODS: Ninety Type 1 diabetes and 60 control eyes were studied. Changes in the retinal nerve fiber layer, ganglion cell layer, and inner nuclear layer thicknesses in all Early Treatment Diabetic Retinopathy Study areas were evaluated. RESULTS: The mean ages were 42.93 ± 13.62 and 41.52 ± 13.05 years in the diabetic and control group, respectively. In 2009, total retinal thickness was higher in diabeticpatients; differences were statistically significant in all except the nasal areas. In both groups, the mean foveal thickness remained the same during the 8 years. Among diabeticpatients, there was a significant reduction in total retinal thickness in all areas excluding the outer temporal one; controls only in the inferior areas. The thickness loss was due to the thinning of the inner retinal layers (inner nuclear layer, ganglion cell layer, and retinal nerve fiber layer). The controls showed a significant diminution in the retinal nerve fiber layer and in the ganglion cell layer areas. The inner nuclear layer showed a diminution in the diabetes mellitus group. CONCLUSION: Before the onset of diabetic retinopathy, Type 1 diabetespatients experience a diminution of their inner retinal layer thicknesses over time, supporting the hypothesis of retinal neurodegeneration.
Authors: Tyler Etheridge; Zhe Liu; Marine Nalbandyan; Spencer Cleland; Barbara A Blodi; Julie A Mares; Steven Bailey; Robert Wallace; Karen Gehrs; Lesley F Tinker; Ronald Gangnon; Amitha Domalpally Journal: Transl Vis Sci Technol Date: 2021-02-05 Impact factor: 3.283