| Literature DB >> 31157268 |
Constantine E Kosmas1, Delia Silverio2, Andreas Sourlas3, Peter D Montan2, Eliscer Guzman1, Mario J Garcia1.
Abstract
Chronic subclinical inflammation is a central process in the pathogenesis of cardiovascular disease (CVD) and it has been linked with both the initiation and progression of atherosclerosis. Several pro-inflammatory cytokines, such as the C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) have been described as independent risk factors for coronary heart disease and promoters of atherogenesis. Thus, extensive research is being conducted to assess the role of anti-inflammatory therapy in the primary and secondary prevention of CVD. Our review aims to provide the clinical and scientific data pertaining to the effects of different anti-inflammatory agents administered in patients with CVD.Entities:
Keywords: Inflammation; anti-inflammatory agents/therapy; cardiovascular disease (CVD); pro-inflammatory cytokines
Year: 2019 PMID: 31157268 PMCID: PMC6511577 DOI: 10.21037/atm.2019.02.34
Source DB: PubMed Journal: Ann Transl Med ISSN: 2305-5839