Rok Barle1, Tomaž Vovk1, Borut Štabuc2, Matej Dobravc Verbič3. 1. Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia. 2. Clinical Department for Gastroenterology, University Medical Centre Ljubljana, Ljubljana, Slovenia. 3. Department of Pharmacy, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Abstract
OBJECTIVES: During cancer treatment, many patients experience chemotherapy-induced nausea and vomiting (CINV), which leads to a lower quality of life and poorer adherence to the subsequent chemotherapy cycles. The aim of the study was to assess antiemetic therapy prescribing and CINV control in the acute phase (24 hours post-chemotherapy) and the delayed phase (days 2-4 post-chemotherapy). Factors influencing CINV control were also determined. METHODS: Information on antiemetic premedication was gathered from patient medical records. Data regarding antiemetic therapy post-discharge and CINV control were in both phases obtained using patient questionnaires. Antiemetic therapy prescribing was compared with internal CINV prevention and control guidelines. Predictive factors for CINV control were evaluated using binary logistic regression. RESULTS: There were 62 patients enrolled in the study, out of which 50 (80.6%) received adequate antiemetic premedication. In the acute phase, 46 (74.2%) patients reported well-controlled CINV, whereas 16 (25.8%) reported uncontrolled CINV. None of the patients was prescribed post-discharge antiemetic therapy as per guidelines. In the delayed phase, CINV was more frequent as 39 (62.9%) patients reported well-controlled CINV, whereas uncontrolled CINV was reported in 23 (37.1%) patients. The predictive factors for overall CINV control were prescription of corticosteroids (OR=9.025, p=0.019) and patient age (OR=0.851, p=0.002). The delayed CINV control was dependent on age (OR=0.885, p=0.030) and acute CINV control (OR=17.377, p=0.001). CONCLUSIONS: The majority of the patients were prescribed adequate antiemetic therapy for the acute phase but not for the delayed phase, which may have resulted in more patients experiencing delayed CINV.
OBJECTIVES: During cancer treatment, many patients experience chemotherapy-induced nausea and vomiting (CINV), which leads to a lower quality of life and poorer adherence to the subsequent chemotherapy cycles. The aim of the study was to assess antiemetic therapy prescribing and CINV control in the acute phase (24 hours post-chemotherapy) and the delayed phase (days 2-4 post-chemotherapy). Factors influencing CINV control were also determined. METHODS: Information on antiemetic premedication was gathered from patient medical records. Data regarding antiemetic therapy post-discharge and CINV control were in both phases obtained using patient questionnaires. Antiemetic therapy prescribing was compared with internal CINV prevention and control guidelines. Predictive factors for CINV control were evaluated using binary logistic regression. RESULTS: There were 62 patients enrolled in the study, out of which 50 (80.6%) received adequate antiemetic premedication. In the acute phase, 46 (74.2%) patients reported well-controlled CINV, whereas 16 (25.8%) reported uncontrolled CINV. None of the patients was prescribed post-discharge antiemetic therapy as per guidelines. In the delayed phase, CINV was more frequent as 39 (62.9%) patients reported well-controlled CINV, whereas uncontrolled CINV was reported in 23 (37.1%) patients. The predictive factors for overall CINV control were prescription of corticosteroids (OR=9.025, p=0.019) and patient age (OR=0.851, p=0.002). The delayed CINV control was dependent on age (OR=0.885, p=0.030) and acute CINV control (OR=17.377, p=0.001). CONCLUSIONS: The majority of the patients were prescribed adequate antiemetic therapy for the acute phase but not for the delayed phase, which may have resulted in more patients experiencing delayed CINV.
Authors: Ethan Basch; Ann Alexis Prestrud; Paul J Hesketh; Mark G Kris; Petra C Feyer; Mark R Somerfield; Maurice Chesney; Rebecca Anne Clark-Snow; Anne Marie Flaherty; Barbara Freundlich; Gary Morrow; Kamakshi V Rao; Rowena N Schwartz; Gary H Lyman Journal: J Clin Oncol Date: 2011-09-26 Impact factor: 44.544
Authors: Ruey Kuen Hsieh; Alexandre Chan; Hoon-Kyo Kim; Shiying Yu; Jong Gwang Kim; Myung-Ah Lee; Johan Dalén; Hun Jung; Yan Ping Liu; Thomas A Burke; Dorothy M K Keefe Journal: Support Care Cancer Date: 2014-08-14 Impact factor: 3.603
Authors: M Aapro; A Molassiotis; M Dicato; I Peláez; Á Rodríguez-Lescure; D Pastorelli; L Ma; T Burke; A Gu; P Gascon; F Roila Journal: Ann Oncol Date: 2012-03-06 Impact factor: 32.976
Authors: Paul J Hesketh; Matti Aapro; Karin Jordan; Lee Schwartzberg; Snezana Bosnjak; Hope Rugo Journal: Biomed Res Int Date: 2015-09-03 Impact factor: 3.411