| Literature DB >> 31156164 |
Andrea Arighi1,2,3, Andrea Di Cristofori4, Chiara Fenoglio1,2,3, Stefano Borsa5, Marianna D'Anca1,2,3, Giorgio Giulio Fumagalli1,2,3,6, Marco Locatelli2,5, Giorgio Carrabba5, Anna Margherita Pietroboni1,2,3, Laura Ghezzi1,2,3, Tiziana Carandini1,2,3, Annalisa Colombi1,2,3, Marta Scarioni1,2,3, Milena Alessandra De Riz1,2,3, Maria Serpente1,2,3, Paolo Maria Rampini5, Elio Scarpini1,2,3, Daniela Galimberti1,3,7.
Abstract
Aquaporin4 (AQP4) is a water channel protein located at astrocyte foot processes that plays a role in glymphatic system, a highly organized fluid transport pathway which seems to be involved in Alzheimer's disease (AD) and normal pressure hydrocephalus (NPH) pathophysiology. Cerebrospinal fluid (CSF) AQP4 levels were determined in 11 patients with AD, 10 patients with NPH, and 9 controls. We found significantly reduced AQP4 in AD patients, a trend in reduction in NPH patients, and a correlation between AQP4 and amyloid-β CSF levels. This study indicates the potential role of AQP4 and glymphatic system in neurodegenerative diseases pathophysiology.Entities:
Keywords: Alzheimer’s disease; Aquaporin 4; glymphatic system; normal pressure zzm321990hydrocephalus
Year: 2019 PMID： 31156164 DOI： 10.3233/JAD-190119
Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472