M Graber1, S Mohr1, L Baptiste1, G Duloquin1, C Blanc-Labarre1, A S Mariet2, M Giroud3, Y Béjot1. 1. Dijon Stroke Registry (Inserm, Santé Publique France), EA7460, university hospital of Dijon, university of Burgundy and Franche-Comté, Dijon, France. 2. Clinical investigation center of Dijon (Inserm CIC 1432), university of Burgundy and Franche Comté, Inserm, biostatistique, biomathématique, pharmacoepidemiologie et maladies infectieuses (B2 PHI), UMR 1181, university Hospital of Dijon, Dijon, France. 3. Dijon Stroke Registry (Inserm, Santé Publique France), EA7460, university hospital of Dijon, university of Burgundy and Franche-Comté, Dijon, France. Electronic address: maurice.giroud@chu-dijon.fr.
Abstract
Evidence from epidemiological studies has demonstrated that outdoor air pollution is now a well-known major problem of public health, mainly in low and middle income countries. Contrasting with myocardial infarction, there are few data on the association of air pollution and stroke. METHODS: We propose a narrative literature review of the effects and the underlying biological mechanisms of short- and long-term exposure to air pollutants on stroke risk and mortality, using the following key-words: stroke, cerebrovascular events, ischemic and haemorrhage stroke, transient ischaemic attack, mortality, air pollution and air pollutants. RESULTS: Twenty-one papers were selected. Air pollution, of which whose small particulate matter are the most toxic, contributes to about one-third of the global burden of stroke. We can identify vulnerable patients with classical neuro-vascular risk factors or a prior history of stroke or transient ischemic attack or persons living in low-income countries. Biological mechanisms of this new morbid association are discussed. CONCLUSION: Air pollution should be recognized as a silent killer inducing stroke whose mortality rates remain elevated by its role as a new modifiable neurovascular risk factor, needing public health policies.
Evidence from epidemiological studies has demonstrated that outdoor air pollution is now a well-known major problem of public health, mainly in low and middle income countries. Contrasting with myocardial infarction, there are few data on the association of air pollution and stroke. METHODS: We propose a narrative literature review of the effects and the underlying biological mechanisms of short- and long-term exposure to air pollutants on stroke risk and mortality, using the following key-words: stroke, cerebrovascular events, ischemic and haemorrhage stroke, transient ischaemic attack, mortality, air pollution and air pollutants. RESULTS: Twenty-one papers were selected. Air pollution, of which whose small particulate matter are the most toxic, contributes to about one-third of the global burden of stroke. We can identify vulnerable patients with classical neuro-vascular risk factors or a prior history of stroke or transient ischemic attack or persons living in low-income countries. Biological mechanisms of this new morbid association are discussed. CONCLUSION: Air pollution should be recognized as a silent killer inducing stroke whose mortality rates remain elevated by its role as a new modifiable neurovascular risk factor, needing public health policies.
Authors: Carmen Adella Sîrbu; Ion Stefan; Rodica Dumitru; Marian Mitrica; Aida Mihaela Manole; Titus Mihai Vasile; Constantin Stefani; Aurelian Emil Ranetti Journal: Healthcare (Basel) Date: 2022-06-23
Authors: Philipp Bücke; Hans Henkes; Guy Arnold; Birgit Herting; Eric Jüttler; Christof Klötzsch; Alfred Lindner; Uwe Mauz; Ludwig Niehaus; Matthias Reinhard; Stefan Waibel; Thomas Horvath; Hansjörg Bäzner; Marta Aguilar Pérez Journal: Eur J Neurol Date: 2021-05-05 Impact factor: 6.288