Literature DB >> 31152093

Keys to unlock androgen receptor translocation.

Amy H Tien1, Marianne D Sadar2.   

Abstract

The androgen receptor (AR) is tightly linked to prostate cancer, but the mechanisms by which AR transactivation is dysregulated during cancer progression are not fully explored. Dagar et al. examined AR translocation to the nucleus to identify a link between heat shock protein 90 (HSP90) and protein kinase A (PKA). Their findings provide a potential mechanism of the initiation of AR transactivation and potential targets for developing and refining treatments for prostate cancer.
© 2019 Tien and Sadar.

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Year:  2019        PMID： 31152093      PMCID： PMC6552410          DOI： 10.1074/jbc.H119.009180

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  9 in total

1.  Identification of genes targeted by the androgen and PKA signaling pathways in prostate cancer cells.

Authors:  G Wang; S J M Jones; M A Marra; M D Sadar
Journal:  Oncogene       Date:  2006-06-05       Impact factor: 9.867

2.  Protein kinase A (PKA) pathway is functionally linked to androgen receptor (AR) in the progression of prostate cancer.

Authors:  Martuza Sarwar; Sabina Sandberg; Per-Anders Abrahamsson; Jenny L Persson
Journal:  Urol Oncol       Date:  2013-02-12       Impact factor: 3.498

3.  Observed correlation between the expression levels of catalytic subunit, Cβ2, of cyclic adenosine monophosphate-dependent protein kinase and prostate cancer aggressiveness.

Authors:  Line Victoria Moen; Håkon Ramberg; Sen Zhao; Helene Hartvedt Grytli; Anita Sveen; Viktor Berge; Rolf I Skotheim; Kristin Austlid Taskén; Bjørn Steen Skålhegg
Journal:  Urol Oncol       Date:  2016-11-09       Impact factor: 3.498

4.  The amino terminus of the human AR is target for corepressor action and antihormone agonism.

Authors:  Helmut Dotzlaw; Udo Moehren; Sigrun Mink; Andrew C B Cato; Jorge A Iñiguez Lluhí; Aria Baniahmad
Journal:  Mol Endocrinol       Date:  2002-04

5.  Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathways.

Authors:  M D Sadar
Journal:  J Biol Chem       Date:  1999-03-19       Impact factor: 5.157

6.  Phosphorylation of HSP90 by protein kinase A is essential for the nuclear translocation of androgen receptor.

Authors:  Manisha Dagar; Julie Pratibha Singh; Gunjan Dagar; Rakesh K Tyagi; Gargi Bagchi
Journal:  J Biol Chem       Date:  2019-04-16       Impact factor: 5.157

7.  Regulation of the 5'-flanking region of the mouse androgen receptor gene by cAMP and androgen.

Authors:  J Lindzey; M Grossmann; M V Kumar; D J Tindall
Journal:  Mol Endocrinol       Date:  1993-12

8.  Identification of three proline-directed phosphorylation sites in the human androgen receptor.

Authors:  Z X Zhou; J A Kemppainen; E M Wilson
Journal:  Mol Endocrinol       Date:  1995-05

9.  Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence.

Authors:  Benjamin Sunkel; Dayong Wu; Zhong Chen; Chiou-Miin Wang; Xiangtao Liu; Zhenqing Ye; Aaron M Horning; Joseph Liu; Devalingam Mahalingam; Horacio Lopez-Nicora; Chun-Lin Lin; Paul J Goodfellow; Steven K Clinton; Victor X Jin; Chun-Liang Chen; Tim H-M Huang; Qianben Wang
Journal:  Nucleic Acids Res       Date:  2016-01-06       Impact factor: 16.971
  9 in total
  5 in total

1.  Phase 1 study of the HSP90 inhibitor onalespib in combination with AT7519, a pan-CDK inhibitor, in patients with advanced solid tumors.

Authors:  Khanh T Do; Geraldine O'Sullivan Coyne; John L Hays; Jeffrey G Supko; Stephen V Liu; Kristin Beebe; Len Neckers; Jane B Trepel; Min-Jung Lee; Tomoko Smyth; Courtney Gannon; Jennifer Hedglin; Alona Muzikansky; Susana Campos; John Lyons; Percy Ivy; James H Doroshow; Alice P Chen; Geoffrey I Shapiro
Journal:  Cancer Chemother Pharmacol       Date:  2020-10-23       Impact factor: 3.333

Review 2.  Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy.

Authors:  Chul Won Yun; Hyung Joo Kim; Ji Ho Lim; Sang Hun Lee
Journal:  Cells       Date:  2019-12-24       Impact factor: 6.600

3.  Identification of key genes and multiple molecular pathways of metastatic process in prostate cancer.

Authors:  Lihuang Guo; Mingyue Lin; Zhenbo Cheng; Yi Chen; Yue Huang; Keqian Xu
Journal:  PeerJ       Date:  2019-10-17       Impact factor: 2.984

4.  Impact of Polyallylamine Hydrochloride on Gene Expression and Karyotypic Stability of Multidrug Resistant Transformed Cells.

Authors:  Larisa Alekseenko; Mariia Shilina; Irina Kozhukharova; Olga Lyublinskaya; Irina Fridlyanskaya; Nikolay Nikolsky; Tatiana Grinchuk
Journal:  Cells       Date:  2020-10-21       Impact factor: 6.600

Review 5.  Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics.

Authors:  Jong Hyeon Yoon; Ki-Sun Kwon
Journal:  Endocrinol Metab (Seoul)       Date:  2021-06-28
  5 in total

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