Priscila Chuhuaicura1, Fernando José Dias1,2, Alain Arias1,2,3, María Florencia Lezcano1, Ramón Fuentes1,2. 1. Dental School, Research Centre for Dental Sciences (CICO), Universidad de La Frontera, Temuco, Chile. 2. Department of Integral Adults Dentistry, Dental School, Universidad de La Frontera, Temuco, Chile. 3. Universidad Adventista de Chile, Chillán, Chile.
Abstract
INTRODUCTION: A relationship between masticatory function and cognition has been reported. It is proposed that mastication changes the blood flow stimulating the perfusion/oxygenation of the brain. This literature review analysed the relation between mastication as a protective factor of the cognitive decline and the changes produced at brain level in adults associated with the brain blood flow. MATERIALS AND METHODS: A systematic review was performed according to the 'Preferred Reporting Items for Systematic Reviews and Meta-Analyses' (PRISMA) criteria in PubMed/MEDLINE, Web of Science, Scopus and Embase. Primary studies were included with no limit on the publication date, conducted on humans, and that established a relation between mastication, brain blood flow and cognitive functions in adult patients. RESULTS: Nine clinical descriptive studies were selected and qualitatively analysed. The collected data suggest the greatest brain areas activated during mastication were the frontotemporal cortex, the caudate nucleus and the thalamus, revealing a positive correlation between chewing intensity and perfusion of the principal trigeminal nucleus. The increase in cerebral blood flow was measured by a local vasodilator effect resulting in increased neuronal metabolism in the region linked to learning and memory. In addition, partially edentulous participants had a marked prefrontal deactivation when they chewed without a prosthesis and presented a decrease in masticatory activity. CONCLUSION: Masticatory function may act as a protective factor in those patients with cognition impairment and neurodegenerative diseases, suggesting some mechanisms among which is the increase of cerebral blood flow.
INTRODUCTION: A relationship between masticatory function and cognition has been reported. It is proposed that mastication changes the blood flow stimulating the perfusion/oxygenation of the brain. This literature review analysed the relation between mastication as a protective factor of the cognitive decline and the changes produced at brain level in adults associated with the brain blood flow. MATERIALS AND METHODS: A systematic review was performed according to the 'Preferred Reporting Items for Systematic Reviews and Meta-Analyses' (PRISMA) criteria in PubMed/MEDLINE, Web of Science, Scopus and Embase. Primary studies were included with no limit on the publication date, conducted on humans, and that established a relation between mastication, brain blood flow and cognitive functions in adult patients. RESULTS: Nine clinical descriptive studies were selected and qualitatively analysed. The collected data suggest the greatest brain areas activated during mastication were the frontotemporal cortex, the caudate nucleus and the thalamus, revealing a positive correlation between chewing intensity and perfusion of the principal trigeminal nucleus. The increase in cerebral blood flow was measured by a local vasodilator effect resulting in increased neuronal metabolism in the region linked to learning and memory. In addition, partially edentulous participants had a marked prefrontal deactivation when they chewed without a prosthesis and presented a decrease in masticatory activity. CONCLUSION: Masticatory function may act as a protective factor in those patients with cognition impairment and neurodegenerative diseases, suggesting some mechanisms among which is the increase of cerebral blood flow.
Authors: T Momose; J Nishikawa; T Watanabe; Y Sasaki; M Senda; K Kubota; Y Sato; M Funakoshi; S Minakuchi Journal: Arch Oral Biol Date: 1997-01 Impact factor: 2.633
Authors: A Viggiano; R Manara; R Conforti; A Paccone; C Secondulfo; L Lorusso; L Sbordone; F Di Salle; M Monda; G Tedeschi; F Esposito Journal: Neuroscience Date: 2015-10-21 Impact factor: 3.590