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Literature DB >> 10688781

Out of Eden: stem cells and their niches.

Abstract

Stem cells are currently in the news for two reasons: the successful cultivation of human embryonic stem cell lines and reports that adult stem cells can differentiate into developmentally unrelated cell types, such as nerve cells into blood cells. Both intrinsic and extrinsic signals regulate stem cell fate and some of these signals have now been identified. Certain aspects of the stem cell microenvironment, or niche, are conserved between tissues, and this can be exploited in the application of stem cells to tissue replacement therapy.

Entities: Gene Species

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Year: 2000 PMID： 10688781 DOI： 10.1126/science.287.5457.1427

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

402 in total

Out of Eden: stem cells and their niches.

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5. Adult-derived stem cells from the liver become myocytes in the heart in vivo.

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8. Evidence that fibroblasts derive from epithelium during tissue fibrosis.

9. Regulation of the mitosis/meiosis decision in the Caenorhabditis elegans germline.

10. Bottom-up approaches in synthetic biology and biomaterials for tissue engineering applications.