| Literature DB >> 31129217 |
Nianfeng Zhang1, Yao Wang1, Juan Kan2, Xiaonan Wu1, Xin Zhang1, Sixue Tang1, Rui Sun1, Jun Liu1, Chunlu Qian1, Changhai Jin3.
Abstract
In this study, the purified water-soluble polysaccharide (ALP-1) from Arctium lappa was used to intervene lipopolysaccharide-induced RAW264.7 macrophage and systemic inflammatory mice. Our results showed that ALP-1 could effectively accommodate the levels of inflammatory cytokines in macrophages and serum of mice, including increased anti-inflammatory cytokine (interleukin-10) and down-regulated pro-inflammatory cytokines (interleukin-1β, interleukin-6 and Tumor Necrosis Factor-α). Moreover, according to our data from 16 s high-throughput sequencing, as compared with LPS model group, the composition of gut microbiota in mice was ameliorated in ALP-1 treatment group. There were higher levels of several probiotics in the stools of ALP-1 treatment group, such as Lactobacillius, Alistipes, Odoribacter, and Phascolarctobacterium. Simultaneously, symbiotic bacteria like Bacteroides were inhibited by ALP-1. Besides, ALP-1 could significantly enhance the production of short chain fatty acids (SCFAs) in gut.Entities:
Keywords: Arctium lappa; Systemic inflammation; Water-soluble polysaccharide
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Year: 2019 PMID： 31129217 DOI： 10.1016/j.ijbiomac.2019.05.171
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953