| Literature DB >> 31119952 |
Ya-Li Zhang1, Xiao Zhang1, Xiang-Zhen Miao1, Yan-Yan Yuan1, Jian Gao1, Xia Li2, Yong-Gang Liu1, Peng Tan1.
Abstract
The effects of coptisine against advanced stage of human pancreatic carcinoma PANC-1 cells was investigated in vitro. Coptisine (25-150 μM) treatment for 48 h caused dose-dependent cell growth inhibition by using CCK-8 assay. Additionally, coptisine was found to inhibit PANC-1 cells metastasis by the wound healing assay. Flow cytometry data indicated that coptisine (25-100 μM) exhibited dose-dependent G1 phase arrest and moderate reduction of S phase. Coptisine was also found to inhibit ERK phosphorylation and total ERK levels. Our research suggested that coptisine would be a potential therapeutic drug for the treatment of pancreatic cancer.Entities:
Keywords: PANC-1 cell; Pancreatic cancer; coptisine
Year: 2019 PMID： 31119952 DOI： 10.1080/10286020.2019.1585820
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569