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Literature DB >> 311186

Chloramphenicol and phenobarbitone--a drug interaction.

R A Bloxham, G M Durbin, T Johnson, M H Winterborn.

Abstract

Two infants with meningitis who were treated with phenobarbitone and high-dose chloramphenicol showed progressive falls in the peak blood levels of chloramphenicol. A standard chloramphenicol dose of 50 mg/kg daily would have produced subtherapeutic blood levels after only a few days. The importance of measuring serial blood chloramphenicol concentrations is stressed.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1979 PMID： 311186 PMCID： PMC1545200 DOI： 10.1136/adc.54.1.76

Source DB: PubMed Journal: Arch Dis Child ISSN： 0003-9888 Impact factor: 3.791

4 in total

1. Pharmacological implications of microsomal enzyme induction.

Authors: A H Conney
Journal: Pharmacol Rev Date: 1967-09 Impact factor: 25.468

2. Chloramphenicol metabolism in the phenobarbital-induced rat. Comparison with thiamphenicol.

Authors: D D Bella; G Marca; V Ferrari; L Bonanomi
Journal: Biochem Pharmacol Date: 1968-12 Impact factor: 5.858

3. The necessity for monitoring chloramphenicol levels when treating neonatal meningitis.

Authors: S B Black; P Levine; H R Shinefield
Journal: J Pediatr Date: 1978-02 Impact factor: 4.406

4. Rapid microbiological assay for chloramphenicol and tetracyclines.

Authors: T J Louie; F P Tally; J G Bartlett; S L Gorbach
Journal: Antimicrob Agents Chemother Date: 1976-06 Impact factor: 5.191

4 in total

10 in total

1. Therapeutic drug monitoring.

Authors: N Buchanan
Journal: Indian J Pediatr Date: 1986 Mar-Apr Impact factor: 1.967

Review 2. Chloramphenicol in the 1980s.

Authors: I Shalit; M I Marks
Journal: Drugs Date: 1984-10 Impact factor: 9.546

Review 10. Genetic and environmental factors associated with variation of human xenobiotic glucuronidation and sulfation.

Authors: B Burchell; M W Coughtrie
Journal: Environ Health Perspect Date: 1997-06 Impact factor: 9.031

10 in total

Chloramphenicol and phenobarbitone--a drug interaction.

1. Pharmacological implications of microsomal enzyme induction.

2. Chloramphenicol metabolism in the phenobarbital-induced rat. Comparison with thiamphenicol.

3. The necessity for monitoring chloramphenicol levels when treating neonatal meningitis.

4. Rapid microbiological assay for chloramphenicol and tetracyclines.

1. Therapeutic drug monitoring.

Review 2. Chloramphenicol in the 1980s.

3. Adverse drug reactions in medical inpatients.

Review 4. Drug level monitoring in paediatric practice.

Review 5. Adverse antibiotic drug interactions.

Review 6. Pharmacokinetic interactions with antiepileptic drugs.

7. Rapid estimation of chloramphenicol clearance in infants and children.

Review 8. Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate.

9. Comparison of methods available for assay of chloramphenicol in clinical specimens.

Review 10. Genetic and environmental factors associated with variation of human xenobiotic glucuronidation and sulfation.