Literature DB >> 311173

The distribution in the eye and the effect on intraocular pressure of clonidine.

H C Innemee, P A van Zwieten.   

Abstract

The distribution of [14C]-clonidine in the eye after intravenous administration and injection into the external carotid arteries was studied in a comparative manner in anesthetized cats. The amount of clonidine accumulated in the eye after intraarterial administration by far exceeded that after intravenous application. In addition the pharmacological effects of clonidine obtained by these two routes of administration were investigated and analyzed. The decrease in intraocular pressure after intravenous administration appears to be much stronger than after intraarterial injection. Obviously, there exists no direct correlation between the clonidine concentration in the eye and the ocular hypotensive effect of this drug.

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Year:  1979        PMID： 311173     DOI： 10.1007/bf00414611

Source DB:  PubMed          Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol        ISSN： 0065-6100


  9 in total

1.  The intraocular pressure response of conscious rabbits to clonidine.

Authors:  R C Allen; M E Langham
Journal:  Invest Ophthalmol       Date:  1976-10

2.  The peripheral and central neural actions of clonidine in normal and glaucomatous eyes.

Authors:  G K Krieglstein; M E Langham; W Leydhecker
Journal:  Invest Ophthalmol Vis Sci       Date:  1978-02       Impact factor: 4.799

Review 3.  Central alpha-adrenergic systems as targets for hypotensive drugs.

Authors: 
Journal:  Rev Physiol Biochem Pharmacol       Date:  1978       Impact factor: 5.545

4.  An increase in intraocular pressure due to clonidine.

Authors:  H C Innemee; P A van Zwieten
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1978-08-16

5.  Clonidine. Effects of a topically administered solution on intraocular pressure and blood pressure in open-angle glaucoma.

Authors:  R Harrison; C S Kaufmann
Journal:  Arch Ophthalmol       Date:  1977-08

6.  [Catapresan (2-(2,6-dichlorphenylamino)-2-imidazoline-hydrochloride)--a new intraocular pressure lowering agent].

Authors:  C Hasslinger
Journal:  Klin Monbl Augenheilkd       Date:  1969-01       Impact factor: 0.700

7.  [On the blood level and secretion of radioactively labeled cardiac glycosides following intraduodenal application in the cat].

Authors:  H Lahrtz; R W Sattler; P A van Zwieten
Journal:  Z Gesamte Exp Med       Date:  1968

8.  Ocular effects of clonidine in cats and monkeys (Macaca irus).

Authors:  A Bill; K Heilmann
Journal:  Exp Eye Res       Date:  1975-11       Impact factor: 3.467

9.  [Ophthalmological studies with dichlorophenylaminoimidazoline with special regard to its effect on intraocular pressure].

Authors:  R Makabe
Journal:  Dtsch Med Wochenschr       Date:  1966-09-23       Impact factor: 0.628
  9 in total
  2 in total

1.  The central ocular hypotensive effect of clonidine.

Authors:  H C Innemee; P A van Zwieten
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1979-04-02

2.  The influence of clonidine on intraocular pressure after topical application to the eyes of anesthetized cats.

Authors:  H C Innemee; A J Hermans; P A van Zwieten
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1979-11
  2 in total

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