Literature DB >> 309734

An increase in intraocular pressure due to clonidine.

H C Innemee, P A van Zwieten.   

Abstract

The rise in intraocular pressure (IOP) observed after the administration of clonidine into the carotid arteries was studied in anesthetized rats and cats. This increase of IOP proved to be blocked by the alpha-sympathicolytic agent piperoxane and by the muscle relaxants d-tubocurarine and gallamine. Our experiments suggest that the elevation of IOP after clonidine injection is due to contraction of the eyelids and extraocular muscles. In these tissues alpha-adrenoceptors seem to play a part.

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Year:  1978        PMID： 309734     DOI： 10.1007/bf00411049

Source DB:  PubMed          Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol        ISSN： 0065-6100


  9 in total

1.  The intraocular pressure response of conscious rabbits to clonidine.

Authors:  R C Allen; M E Langham
Journal:  Invest Ophthalmol       Date:  1976-10

2.  Clonidine. Effects of a topically administered solution on intraocular pressure and blood pressure in open-angle glaucoma.

Authors:  R Harrison; C S Kaufmann
Journal:  Arch Ophthalmol       Date:  1977-08

3.  The influence of drugs that change blood pressure on intraocular pressure in the anaesthetized rat.

Authors:  W Schulz; P A van Zwieten
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1971

4.  [Catapresan (2-(2,6-dichlorphenylamino)-2-imidazoline-hydrochloride)--a new intraocular pressure lowering agent].

Authors:  C Hasslinger
Journal:  Klin Monbl Augenheilkd       Date:  1969-01       Impact factor: 0.700

5.  Continuous determination of intraocular pressure in the rat.

Authors:  F K Ohnesorge; H Soyka; P A van Zwieten
Journal:  Exp Eye Res       Date:  1968-01       Impact factor: 3.467

6.  Characterization of stimulation of mammalian extraocular muscles by cholinomimetics.

Authors:  I S Sanghvi; C M Smith
Journal:  J Pharmacol Exp Ther       Date:  1969-06       Impact factor: 4.030

7.  Ocular effects of clonidine in cats and monkeys (Macaca irus).

Authors:  A Bill; K Heilmann
Journal:  Exp Eye Res       Date:  1975-11       Impact factor: 3.467

8.  [Ophthalmological studies with dichlorophenylaminoimidazoline with special regard to its effect on intraocular pressure].

Authors:  R Makabe
Journal:  Dtsch Med Wochenschr       Date:  1966-09-23       Impact factor: 0.628

9.  [Pharmacological effects of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride, a new, antihypertensive substance].

Authors:  W Hoefke; W Kobinger
Journal:  Arzneimittelforschung       Date:  1966-08
  9 in total
  6 in total

1.  The distribution in the eye and the effect on intraocular pressure of clonidine.

Authors:  H C Innemee; P A van Zwieten
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1979-01-15

2.  The influence of clonidine on intraocular pressure.

Authors:  H C Innemee; P A van Zwieten
Journal:  Doc Ophthalmol       Date:  1979-03-15       Impact factor: 2.379

3.  The central ocular hypotensive effect of clonidine.

Authors:  H C Innemee; P A van Zwieten
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1979-04-02

4.  The influence of clonidine on intraocular pressure after topical application to the eyes of anesthetized cats.

Authors:  H C Innemee; A J Hermans; P A van Zwieten
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1979-11

5.  Differential effects of selective alpha 1- and alpha 2-adrenoceptor agonists on intraocular pressure in the conscious rabbit.

Authors:  H C Innemee; A de Jonge; J C van Meel; P B Timmermans; P A van Zwieten
Journal:  Doc Ophthalmol       Date:  1982-01-29       Impact factor: 2.379

6.  The effect of selective alpha 1- and alpha 2-adrenoceptor stimulation on intraocular pressure in the conscious rabbit.

Authors:  H C Innemee; A de Jonge; J C van Meel; P B Timmermans; P A van Zwieten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-07       Impact factor: 3.000
  6 in total

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