Franck Bruyère1,2, Abdel Rahmène Azzouzi3, Jean-Philippe Lavigne4,5, Stéphane Droupy6, Patrick Coloby7, Xavier Game8, Gilles Karsenty9, Bertrand Issartel10, Alain Ruffion11,12, Vincent Misrai13, Albert Sotto4,14, Francois-André Allaert15,16. 1. Urologie, CHRU Bretonneau, Tours, France, f.bruyere@chu-tours.fr. 2. Université François Rabelais de Tours, Tours, France, f.bruyere@chu-tours.fr. 3. Urologie, CHU Angers, Angers, France. 4. Inserm U1407, Université de Montpellier, Nîmes, France. 5. Service de Microbiologie, CHU Caremeau, Nîmes, France. 6. Urologie, CHU Caremeau, Nîmes, France. 7. Urologie, CH Pontoise, Pontoise, France. 8. Urologie, CHU Rangueil, Toulouse, France. 9. Urologie et Transplantation Rénale, Aix Marseille Université, CHU La Conception, Marseille, France. 10. Centre de Vaccination et Médecine Interne et Maladies Infectieuses, Villeurbanne, France. 11. Urologie, Hospices Civils de Lyon, Centre Hospitalier Lyon sud, Pierre Benite, France. 12. Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France. 13. Urologie, Clinique Pasteur, Toulouse, France. 14. Maladies Infectieuses et Tropicales, CHU Caremeau, Nîmes, France. 15. CEN Nutriment, Impasse Françoise Dolto, Dijon, France. 16. Chaire d'évaluation Médicale des Allégations de Santé, Dijon, France.
Abstract
OBJECTIVES: The purpose of the study was to compare the efficacy of a product containing cranberry and propolis (DUAB) to placebo for reducing frequency of cystitis in women with recurrent acute cystitis. METHOD: A multicenter, placebo-controlled, randomized study of women aged >18 years with at least 4 episodes of cystitis in the previous 12 months was performed. The number of cystitis episodes over a 6-month follow-up was the primary end point. RESULTS: Forty-two women were included in the cranberry + propolis group, and 43 women were in the placebo group. The mean age was 53 ± 18 years, with 6.2 ± 3.6 cystitis episodes in the previous year, with no differences between the 2 groups. The mean number of infections was lower in the propolis + cranberry group (respectively, 2.3 ± 1.8 vs. 3.1 ± 1.8). The total number of cystitis episodes in the first 3 months was lower in the propolis + cranberry group (0.7 ± 1.1 vs. 1.3 ± 1.1, p = 0.0257) after adjusting for water consumption. The mean time to onset of the first urinary tract infection (UTI) was also significantly longer in the propolis + cranberry group (69.9 ± 45.8 days vs. 43.3 ± 45.9, p = 0.0258). Tolerance to the treatments was good and comparable in both groups. CONCLUSIONS: We demonstrate for the first time that cranberry and propolis supplementation significantly reduces the incidence of UTIs during the first 3 months and delays the onset of an episode of cystitis.
OBJECTIVES: The purpose of the study was to compare the efficacy of a product containing cranberry and propolis (DUAB) to placebo for reducing frequency of cystitis in women with recurrent acute cystitis. METHOD: A multicenter, placebo-controlled, randomized study of women aged >18 years with at least 4 episodes of cystitis in the previous 12 months was performed. The number of cystitis episodes over a 6-month follow-up was the primary end point. RESULTS: Forty-two women were included in the cranberry + propolis group, and 43 women were in the placebo group. The mean age was 53 ± 18 years, with 6.2 ± 3.6 cystitis episodes in the previous year, with no differences between the 2 groups. The mean number of infections was lower in the propolis + cranberry group (respectively, 2.3 ± 1.8 vs. 3.1 ± 1.8). The total number of cystitis episodes in the first 3 months was lower in the propolis + cranberry group (0.7 ± 1.1 vs. 1.3 ± 1.1, p = 0.0257) after adjusting for water consumption. The mean time to onset of the first urinary tract infection (UTI) was also significantly longer in the propolis + cranberry group (69.9 ± 45.8 days vs. 43.3 ± 45.9, p = 0.0258). Tolerance to the treatments was good and comparable in both groups. CONCLUSIONS: We demonstrate for the first time that cranberry and propolis supplementation significantly reduces the incidence of UTIs during the first 3 months and delays the onset of an episode of cystitis.
Authors: Paul Loubet; Jérémy Ranfaing; Aurélien Dinh; Catherine Dunyach-Remy; Louis Bernard; Franck Bruyère; Jean-Philippe Lavigne; Albert Sotto Journal: Front Microbiol Date: 2020-07-03 Impact factor: 5.640
Authors: Timothy J Straub; Wen-Chi Chou; Abigail L Manson; Henry L Schreiber; Bruce J Walker; Christopher A Desjardins; Sinéad B Chapman; Kerrie L Kaspar; Orsalem J Kahsai; Elizabeth Traylor; Karen W Dodson; Meredith A J Hullar; Scott J Hultgren; Christina Khoo; Ashlee M Earl Journal: BMC Microbiol Date: 2021-02-18 Impact factor: 3.605
Authors: Michael Jeitler; Andreas Michalsen; Andreas Schwiertz; Christian S Kessler; Daniela Koppold-Liebscher; Julia Grasme; Farid I Kandil; Nico Steckhan Journal: J Integr Complement Med Date: 2022-03-14