Fatima Y Ismail1,2, Bruce K Shapiro3. 1. Department of Pediatrics, UAE University, Al-Ain, United Arab Emirates. 2. Department of Neurology (adjunct), Johns Hopkins School of Medicine. 3. Department of Neurology and Developmental Medicine, The Kennedy Krieger Institute, Baltimore, Maryland, USA.
Abstract
PURPOSE OF REVIEW: The purpose of this review is to highlight the origin and evolution of the field of neurodevelopmental disabilities and describe the main construct(s) upon which the current classification of neurodevelopmental disorders is based. RECENT FINDINGS: We address the following questions: Are neurodevelopmental disorders independent entities? Why is it desirable to understand the neurobiological substrate for these disorders? What new knowledge have we generated by leveraging advances in neuroscience, genetics, and neuroimaging? And finally, is the current construct, that is based on functional classification, still useful? SUMMARY: As our biological understanding of brain-behavior disorders evolves, we ought to re-evaluate the current classification system and expand it into a multidimensional classification that takes into account behavioral profiles and underlying mechanisms.
PURPOSE OF REVIEW: The purpose of this review is to highlight the origin and evolution of the field of neurodevelopmental disabilities and describe the main construct(s) upon which the current classification of neurodevelopmental disorders is based. RECENT FINDINGS: We address the following questions: Are neurodevelopmental disorders independent entities? Why is it desirable to understand the neurobiological substrate for these disorders? What new knowledge have we generated by leveraging advances in neuroscience, genetics, and neuroimaging? And finally, is the current construct, that is based on functional classification, still useful? SUMMARY: As our biological understanding of brain-behavior disorders evolves, we ought to re-evaluate the current classification system and expand it into a multidimensional classification that takes into account behavioral profiles and underlying mechanisms.
Authors: Suma P Shankar; Kristin Grimsrud; Louise Lanoue; Alena Egense; Brandon Willis; Johanna Hörberg; Lama AlAbdi; Klaus Mayer; Koray Ütkür; Kristin G Monaghan; Joel Krier; Joan Stoler; Maha Alnemer; Prabhu R Shankar; Raffael Schaffrath; Fowzan S Alkuraya; Ulrich Brinkmann; Leif A Eriksson; Kent Lloyd; Katherine A Rauen Journal: Genet Med Date: 2022-04-28 Impact factor: 8.864
Authors: Manpreet Kaur; Jeremy Costello; Elyse Willis; Karen Kelm; Marek Z Reformat; Francois V Bolduc Journal: J Med Internet Res Date: 2022-08-05 Impact factor: 7.076