Shenghang Wang1,2,3, Jie Luo1,2,3, Huanhuan Lv1,2,3, Zhihao Zhang1,2,3, Jiancheng Yang1,2,3, Dandan Dong1,2,3, Yanwen Fang4, Lijiang Hu4, Mengyu Liu4, Zhongcai Liao4, Jun Li4, Zhicai Fang4, Yunpeng Wei1,3, Wei Han1,3, Atik Badshah Shaikh1,3, Dachuan Yin1,2,3, Peng Shang5,6. 1. Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, 518057, China. 2. School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, Shaanxi, China. 3. Key Laboratory for Space Biosciences and Biotechnology, Northwestern Polytechnical University, Xi'an, 710072, Shaanxi, China. 4. Zhejiang Heye Health Technology Co., Ltd., Anji, Huzhou, China. 5. Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, 518057, China. shangpeng@nwpu.edu.cn. 6. Key Laboratory for Space Biosciences and Biotechnology, Northwestern Polytechnical University, Xi'an, 710072, Shaanxi, China. shangpeng@nwpu.edu.cn.
Abstract
OBJECTIVES: We aimed to evaluate the biological effects of high static magnetic field (HiSMF, 2-12 Tesla [T]) exposure on mice in a stable and effective breeding environment in the chamber of a superconducting magnet. METHODS: C57BL/6 mice were bred in the geomagnetic field and HiSMF with different magnetic field strengths (2-4 T, 6-8 T, and 10-12 T) for 28 days. The body weight, blood indices, organ coefficients, and histomorphology of major organs were analyzed. RESULTS: The results showed that the HiSMF had no significant effect on the body weight, organ coefficients, or histomorphology of major organs in mice. The HiSMF had no effect on most routine blood and biochemical indices, but the value of the mean corpuscular hemoglobin (MCH) was increased in the 2-4 T group compared with that of the other groups, and the uric acid level (UA) was decreased in the three HiSMF groups compared with that of the control group. CONCLUSION: The C57BL/6 mice were not affected when they were exposed to different HiSMF environments for 28 days. KEY POINTS: • No physiological problems were observed in mice with long-term whole-body exposure to HiSMF.
OBJECTIVES: We aimed to evaluate the biological effects of high static magnetic field (HiSMF, 2-12 Tesla [T]) exposure on mice in a stable and effective breeding environment in the chamber of a superconducting magnet. METHODS: C57BL/6 mice were bred in the geomagnetic field and HiSMF with different magnetic field strengths (2-4 T, 6-8 T, and 10-12 T) for 28 days. The body weight, blood indices, organ coefficients, and histomorphology of major organs were analyzed. RESULTS: The results showed that the HiSMF had no significant effect on the body weight, organ coefficients, or histomorphology of major organs in mice. The HiSMF had no effect on most routine blood and biochemical indices, but the value of the mean corpuscular hemoglobin (MCH) was increased in the 2-4 T group compared with that of the other groups, and the uric acid level (UA) was decreased in the three HiSMF groups compared with that of the control group. CONCLUSION: The C57BL/6 mice were not affected when they were exposed to different HiSMF environments for 28 days. KEY POINTS: • No physiological problems were observed in mice with long-term whole-body exposure to HiSMF.
Entities:
Keywords:
Magnetic fields; Mice, inbred C57BL; Organ size; Safety management; Staining and labeling
Authors: Ivan Tkáč; Michael A Benneyworth; Tessa Nichols-Meade; Elizabeth L Steuer; Sarah N Larson; Gregory J Metzger; Kâmil Uğurbil Journal: Magn Reson Med Date: 2021-04-06 Impact factor: 4.668
Authors: Valentina Hartwig; Giorgio Virgili; F Ederica Mattei; Cristiano Biagini; Stefania Romeo; Olga Zeni; Maria Rosaria Scarfì; Rita Massa; Francesco Campanella; Luigi Landini; Fabriziomaria Gobba; Alberto Modenese; Giulio Giovannetti Journal: Med Biol Eng Comput Date: 2021-09-29 Impact factor: 2.602