Literature DB >> 31103451

Sequential drug delivery to modulate macrophage behavior and enhance implant integration.

Erin M O'Brien1, Gregory E Risser1, Kara L Spiller2.   

Abstract

Macrophages are major upstream regulators of the inflammatory response to implanted biomaterials. Sequential functions of distinct macrophage phenotypes are essential to the normal tissue repair process, which ideally results in vascularization and integration of implants. Improper timing of M1 or M2 macrophage activation results in dysfunctional healing in the form of chronic inflammation or fibrous encapsulation of the implant. Thus, biphasic drug delivery systems that modulate macrophage behavior are an appealing approach to promoting implant integration. In this review, we describe the timing and roles of macrophage phenotypes in healing, then highlight current drug delivery systems designed to sequentially modulate macrophage behavior.
Copyright © 2019 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Angiogenesis; Implant integration; Macrophage

Year:  2019        PMID： 31103451      PMCID： PMC6858522          DOI： 10.1016/j.addr.2019.05.005

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN： 0169-409X            Impact factor:   15.470


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