Literature DB >> 3110253

Increased level of thyroglobulin mRNA in a human familial goiter.

A Monticelli, V E Avvedimento, A Mariano, C Marcocci, L Chiovato, G F Fenzi, A Pinchera, S Varrone.   

Abstract

Thyroglobulin (Tg) and its specific mRNA were analyzed in the thyroid gland of two cases of familial goiter. A three-fold increase in the level of stable protein and functional Tg mRNA was found in the goiter of one of the two patients in whom a desiodase defect was demonstrated. Normal concentrations of both Tg and its mRNA were found in the other goiter in which no enzymatic defect could be shown. Our results suggest that the increase of Tg mRNA levels found in the goiter with a desiodase defect was due to a chronic stimulation of the gland by TSH.

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Year:  1987        PMID： 3110253     DOI： 10.1007/BF03347155

Source DB:  PubMed          Journal:  J Endocrinol Invest        ISSN： 0391-4097            Impact factor:   4.256


  20 in total

1.  Afrikander cattle congenital goiter: characteristics of the defective 19S thyroglobulin synthesis.

Authors:  M Pammenter; A Bester; C Albrecht; P van Jaarsveld
Journal:  Endocrinology       Date:  1979-06       Impact factor: 4.736

2.  Control of thyroglobulin synthesis and secretion. (First of two parts).

Authors:  A J Van Herle; G Vassart; J E Dumont
Journal:  N Engl J Med       Date:  1979-08-02       Impact factor: 91.245

3.  Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

Authors:  P W Rigby; M Dieckmann; C Rhodes; P Berg
Journal:  J Mol Biol       Date:  1977-06-15       Impact factor: 5.469

4.  Serum thyroglobulin levels in healthy subjects and in patients with thyroid disease.

Authors:  G Torrigiani; D Doniach; I M Roitt
Journal:  J Clin Endocrinol Metab       Date:  1969-03       Impact factor: 5.958

5.  Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

Authors:  P S Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

6.  Construction of recombinant plasmids containing rat thyroglobulin mRNA sequences.

Authors:  R Di Lauro; S Obici; A M Acquaviva; C G Alvino
Journal:  Gene       Date:  1982 Jul-Aug       Impact factor: 3.688

7.  Modulation of thyroglobulin messenger RNA level by thyrotropin in cultured thyroid cells.

Authors:  J Chebath; O Chabaud; J Mauchamp
Journal:  Nucleic Acids Res       Date:  1979-07-25       Impact factor: 16.971

8.  Two abnormal thyroglobulin-like polypeptides are produced from Afrikander cattle congenital goiter mRNA.

Authors:  V P Tassi; R Di Lauro; P Van Jaarsveld; C G Alvino
Journal:  J Biol Chem       Date:  1984-08-25       Impact factor: 5.157

9.  A radioimmunoassay for human thyroglobulin: methodology and clinical applications.

Authors:  V Pezzino; P Cozzani; S Filetti; A Galbiati; E Lisi; S Squatrito; R Vigneri
Journal:  Eur J Clin Invest       Date:  1977-12       Impact factor: 4.686

10.  Thyrotropin controls transcription of the thyroglobulin gene.

Authors:  B Van Heuverswyn; C Streydio; H Brocas; S Refetoff; J Dumont; G Vassart
Journal:  Proc Natl Acad Sci U S A       Date:  1984-10       Impact factor: 11.205
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