Andrea Sikora Newsome1, Brittany D Bissell2, Lisa D Burry3, Aubrey A Defayette4, David J Gagnon5, Brian W Gilbert6, C Joseph Kramer7, Christopher J Miller8, Michael Semanco9, Melanie N Smith10, Drayton A Hammond11. 1. The University of Georgia College of Pharmacy, 1120 15th Street, HM-118, Augusta, GA 30912, United States. Electronic address: andnewsome@augusta.edu. 2. Department of Pharmacy Services, University of Kentucky Healthcare, 800 Rose Street, H110, Lexington, KY 40536, United States. Electronic address: brittany.bissell@uky.edu. 3. University of Toronto, Leslie Dan Faculty of Pharmacy & Sinai Health System, 600 University Ave, Rm 18-377 Toronto, Ontario, Canada. Electronic address: lisa.burry@sinaihealthsystem.ca. 4. D'Youville School of Pharmacy, 320 Porter Avenue, Buffalo, NY 14213, United States. Electronic address: gawrona@dyc.edu. 5. Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, United States. Electronic address: dgagnon@mmc.org. 6. Wesley Medical Center, 550 N. Hillside Ave, Wichita, KS 67214, United States. 7. Theravance Biopharma US, Inc., 300 Harrison Ave, #2-215, Boston, MA 02118, United States. 8. University of Colorado Hospital, 12605 E. 16th Ave, Aurora, CO 80045, United States. Electronic address: christopher.miller@uchealth.org. 9. Lakeland Regional Health, 1324 Lakeland Hills Blvd., Lakeland, FL 33805, United States. Electronic address: Michael.Semanco@myLRH.org. 10. Medical University of South Carolina, 150 Ashley Avenue, Charleston, SC 29425, United States. 11. Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, United States. Electronic address: drayton_hammond@rush.edu.
Abstract
PURPOSE: To summarize selected original critical care pharmacotherapy research published in 2018. MATERIALS AND METHODS: The Critical Care Pharmacotherapy Literature Update (CCPLU) Group screened 32 journals monthly for impactful articles and reviewed 100 articles during 2018. Grading of Recommendations, Assessment, Development and Evaluations (GRADE) criteria were applied to all relevant articles included in the monthly CCPLU. Articles with a 1A grade, including one clinical practice guideline, two meta-analyses, and ten original research trials, were selected for review. RESULTS: Clinical practice guidelines for the management of pain, agitation, delirium, immobility, and sleep disruption were summarized. Meta-analyses on the role of corticosteroids in sepsis and early enteral nutrition were reviewed. Included original research trials evaluated corticosteroids in sepsis, enteral and parenteral nutrition in patients with shock, tenecteplase in acute ischemic stroke, antipsychotics for the treatment of intensive care unit delirium, vasopressors in cardiogenic shock, balanced crystalloids and saline for fluid administration, and meropenem and piperacillin-tazobactam for treatment of resistant Gram-negative organisms. CONCLUSION: This clinical review and expert commentary of impactful critical care pharmacotherapy publications in 2018 provides perspectives and insights for the critical care practitioner.
PURPOSE: To summarize selected original critical care pharmacotherapy research published in 2018. MATERIALS AND METHODS: The Critical Care Pharmacotherapy Literature Update (CCPLU) Group screened 32 journals monthly for impactful articles and reviewed 100 articles during 2018. Grading of Recommendations, Assessment, Development and Evaluations (GRADE) criteria were applied to all relevant articles included in the monthly CCPLU. Articles with a 1A grade, including one clinical practice guideline, two meta-analyses, and ten original research trials, were selected for review. RESULTS: Clinical practice guidelines for the management of pain, agitation, delirium, immobility, and sleep disruption were summarized. Meta-analyses on the role of corticosteroids in sepsis and early enteral nutrition were reviewed. Included original research trials evaluated corticosteroids in sepsis, enteral and parenteral nutrition in patients with shock, tenecteplase in acute ischemic stroke, antipsychotics for the treatment of intensive care unit delirium, vasopressors in cardiogenic shock, balanced crystalloids and saline for fluid administration, and meropenem and piperacillin-tazobactam for treatment of resistant Gram-negative organisms. CONCLUSION: This clinical review and expert commentary of impactful critical care pharmacotherapy publications in 2018 provides perspectives and insights for the critical care practitioner.
Authors: Melanie Smith Condeni; Alyson T Basting; Patrick G Costello; Ashley DePriest; Evert A Eriksson; Heather Evans; Kristie Hertel; Andre L Holder; Alyssa N Kester; Kinsey R Kowalski; Carolyn Magee Bell; Barbara McLean; Michael Reichert; Melissa Santibañez; Patrick M Wieruszewski; Andrea Sikora Newsome Journal: J Crit Care Date: 2020-12-27 Impact factor: 3.425