| Literature DB >> 31099046 |
Shanshan Lu1,2, Xue Yang1, Chudong Wang1, Siqi Chen1, Shuang Lu1,3, Weitao Yan3, Kun Xiong3, Fengxia Liu4, Jie Yan1,4.
Abstract
Given the importance of non-coding RNAs in modulating normal brain functions and their implications in the treatment of neurological disorders, non-coding RNA-based diagnostic and therapeutic strategies have shown great clinical potential. Circular RNAs (circRNAs) have emerged as potentially important players in this field. Recent studies have indicated that circRNAs might play vital roles in Alzheimer's disease, Parkinson's disease, ischemic brain injury, and neurotoxicity. However, the mechanisms of action of circRNAs have not been fully characterized. We aimed to review recent advances in circRNA research in the brain to provide new insights on the roles of circRNAs in neurological disorders.Entities:
Keywords: Alzheimer's disease; Parkinson's disease; circRNA; neurotoxicity; stroke
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Year: 2019 PMID： 31099046 DOI： 10.1111/jnc.14724
Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372