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Literature DB >> 31092696

Advances in therapeutic applications of extracellular vesicles.

Oscar P B Wiklander^1,2, Meadhbh Á Brennan^3,4,5, Jan Lötvall⁶, Xandra O Breakefield⁴, Samir El Andaloussi^1,2.

Abstract

Extracellular vesicles (EVs) are nanometer-sized, lipid membrane-enclosed vesicles secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid species of the source cell. EVs act as important mediators of intercellular communication that influence both physiological and pathological conditions. Given their ability to transfer bioactive components and surmount biological barriers, EVs are increasingly being explored as potential therapeutic agents. EVs can potentiate tissue regeneration, participate in immune modulation, and function as potential alternatives to stem cell therapy, and bioengineered EVs can act as delivery vehicles for therapeutic agents. Here, we cover recent approaches and advances of EV-based therapies.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Year: 2019 PMID： 31092696 PMCID： PMC7104415 DOI： 10.1126/scitranslmed.aav8521

Source DB: PubMed Journal: Sci Transl Med ISSN： 1946-6234 Impact factor: 17.956

175 in total

1. The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting.

Authors: Laura Santangelo; Giorgio Giurato; Carla Cicchini; Claudia Montaldo; Carmine Mancone; Roberta Tarallo; Cecilia Battistelli; Tonino Alonzi; Alessandro Weisz; Marco Tripodi
Journal: Cell Rep Date: 2016-10-11 Impact factor: 9.423

Review 2. Extracellular vesicles: biology and emerging therapeutic opportunities.

Authors: Samir EL Andaloussi; Imre Mäger; Xandra O Breakefield; Matthew J A Wood
Journal: Nat Rev Drug Discov Date: 2013-04-15 Impact factor: 84.694

3. Generation and testing of clinical-grade exosomes for pancreatic cancer.

Authors: Mayela Mendt; Sushrut Kamerkar; Hikaru Sugimoto; Kathleen M McAndrews; Chia-Chin Wu; Mihai Gagea; Sujuan Yang; Elena V Rodriges Blanko; Qian Peng; Xiaoyan Ma; Joseph R Marszalek; Anirban Maitra; Cassian Yee; Katayoun Rezvani; Elizabeth Shpall; Valerie S LeBleu; Raghu Kalluri
Journal: JCI Insight Date: 2018-04-19

4. Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation.

Authors: L von Bahr; I Batsis; G Moll; M Hägg; A Szakos; B Sundberg; M Uzunel; O Ringden; K Le Blanc
Journal: Stem Cells Date: 2012-07 Impact factor: 6.277

5. CD8(+) T-cell responses to adeno-associated virus capsid in humans.

Authors: Federico Mingozzi; Marcela V Maus; Daniel J Hui; Denise E Sabatino; Samuel L Murphy; John E J Rasko; Margaret V Ragni; Catherine S Manno; Jurg Sommer; Haiyan Jiang; Glenn F Pierce; Hildegund C J Ertl; Katherine A High
Journal: Nat Med Date: 2007-03-18 Impact factor: 53.440

6. Barriers to horizontal cell transformation by extracellular vesicles containing oncogenic H-ras.

Authors: Tae Hoon Lee; Shilpa Chennakrishnaiah; Brian Meehan; Laura Montermini; Delphine Garnier; Esterina D'Asti; Wenyang Hou; Nathalie Magnus; Tenzin Gayden; Nada Jabado; Kolja Eppert; Loydie Majewska; Janusz Rak
Journal: Oncotarget Date: 2016-08-09

7. Vascular endothelial growth factor mediates the therapeutic efficacy of mesenchymal stem cell-derived extracellular vesicles against neonatal hyperoxic lung injury.

Authors: So Yoon Ahn; Won Soon Park; Jee Yin Ahn; Yun Sil Chang; Young Eun Kim; Dong Kyung Sung; Se In Sung
Journal: Exp Mol Med Date: 2018-04-13 Impact factor: 8.718

8. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.

Authors: Johan Skog; Tom Würdinger; Sjoerd van Rijn; Dimphna H Meijer; Laura Gainche; Miguel Sena-Esteves; William T Curry; Bob S Carter; Anna M Krichevsky; Xandra O Breakefield
Journal: Nat Cell Biol Date: 2008-11-16 Impact factor: 28.824

9. Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles.

Authors: Eduardo Reátegui; Kristan E van der Vos; Charles P Lai; Mahnaz Zeinali; Nadia A Atai; Berent Aldikacti; Frederick P Floyd; Aimal H Khankhel; Vishal Thapar; Fred H Hochberg; Lecia V Sequist; Brian V Nahed; Bob S Carter; Mehmet Toner; Leonora Balaj; David T Ting; Xandra O Breakefield; Shannon L Stott
Journal: Nat Commun Date: 2018-01-12 Impact factor: 14.919

10. Mesenchymal stem cell-derived extracellular vesicles attenuate influenza virus-induced acute lung injury in a pig model.

Authors: Mahesh Khatri; Levi Arthur Richardson; Tea Meulia
Journal: Stem Cell Res Ther Date: 2018-01-29 Impact factor: 6.832

201 in total

Review 1. Emergence of the Stem Cell Secretome in Regenerative Engineering.

Authors: Leila Daneshmandi; Shiv Shah; Tahereh Jafari; Maumita Bhattacharjee; Deandra Momah; Nikoo Saveh-Shemshaki; Kevin W-H Lo; Cato T Laurencin
Journal: Trends Biotechnol Date: 2020-07-01 Impact factor: 19.536

2. Extracellular Vesicle Therapeutics in Regenerative Medicine.

Authors: Aya Imafuku; Sebastian Sjoqvist
Journal: Adv Exp Med Biol Date: 2021 Impact factor: 2.622

3. Postlymphadenectomy Analysis of Exosomes from Lymphatic Exudate/Exudative Seroma of Melanoma Patients.

Authors: Susana García-Silva; Pilar Ximénez-Embún; Javier Muñoz; Héctor Peinado
Journal: Methods Mol Biol Date: 2021

4. Alveolar macrophage-derived extracellular vesicles inhibit endosomal fusion of influenza virus.

Authors: Daniel J Schneider; Katherine A Smith; Catrina E Latuszek; Carol A Wilke; Danny M Lyons; Loka R Penke; Jennifer M Speth; Matangi Marthi; Joel A Swanson; Bethany B Moore; Adam S Lauring; Marc Peters-Golden
Journal: EMBO J Date: 2020-07-09 Impact factor: 11.598

5. In vivo two-photon microscopy reveals the contribution of Sox9⁺ cell to kidney regeneration in a mouse model with extracellular vesicle treatment.

Authors: Kaiyue Zhang; Shang Chen; Huimin Sun; Lina Wang; Huifang Li; Jinglei Zhao; Chuyue Zhang; Nana Li; Zhikun Guo; Zhibo Han; Zhong-Chao Han; Guoguang Zheng; Xiangmei Chen; Zongjin Li
Journal: J Biol Chem Date: 2020-07-08 Impact factor: 5.157