| Literature DB >> 31091976 |
Jianheng Li1, Jijun Hao2,3.
Abstract
Tripterygium wilfordii Hook F. (TWHF), a traditional Chinese medicine, has been widely used to treat autoimmune and inflammatory diseases including rheumatoid arthritis, systemic lupus erythematosus and dermatomyositis in China. Recently, studies have demonstrated that the bioactive components of TWHF have effective therapeutic potential for neurodegenerative diseases including Alzheimer's disease, Parkinson's disease and Multiple Sclerosis. In this paper, we summarize the research progress of triptolide and celastrol (the two major TWHF components) as well as their analogues in the treatment of neurodegenerative diseases. In addition, we review and discuss the molecular mechanisms and structure features of those two bioactive TWHF components, highlighting their therapeutic promise in neurodegenerative diseases.Entities:
Keywords: Alzheimer’s Disease; Celastrol; Central Nervous System; Parkinson’s Disease; Review; Triptolide
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Year: 2019 PMID： 31091976 DOI： 10.1142/S0192415X1950040X
Source DB: PubMed Journal: Am J Chin Med ISSN： 0192-415X Impact factor: 4.667