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Literature DB >> 3108656

Inhibition of ADP-ribosylation of histone H1 by analogs of diadenosine 5',5'''-p1,p4-tetraphosphate.

H Suzuki, Y Tanaka, D T Buonamassa, B Farina, E Leone.

Abstract

The effects of analogs of diadenosine 5',5'''-p1,p4-tetraphosphate (Ap4A) were examined on the ADP-ribosylation reaction of histone H1 catalysed by purified bovine thymus poly(ADP-ribose)transferase. Among the compounds tested, epsilon Ap4A and ApCH2pppA were shown to be the most efficient inhibitors of the enzyme. From kinetic studies of their action, it appears that epsilon Ap4A and ApCH2pppA might be 'mixed type' inhibitors.

Entities: Chemical Species

Mesh：

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Year: 1987 PMID： 3108656 DOI： 10.1007/bf00221908

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

19 in total

1. Bovine thymus poly(ADP-ribose) polymerase histone-dependent and Mg2+-dependent reaction.

Authors: Y Tanaka; T Hashida; H Yoshihara; K Yoshihara
Journal: J Biol Chem Date: 1979-12-25 Impact factor: 5.157

2. Induction of sister chromatid exchanges by nicotinamide in Chinese hamster lung fibroblasts and human lymphoblastoid cells.

Authors: T Utakoji; K Hosoda; K Umezawa; M Sawamura; T Matsushima; M Miwa; T Sugimura
Journal: Biochem Biophys Res Commun Date: 1979-10-29 Impact factor: 3.575

3. Interrelationship between poly (ADP-Rib) synthesis, intracellular NAD levels, and muscle or cartilage differentiation from mesodermal cells of embryonic chick limb.

Authors: A I Caplan; M J Rosenberg
Journal: Proc Natl Acad Sci U S A Date: 1975-05 Impact factor: 11.205

4. Bovine thymus poly(adenosine diphosphate ribose) polymerase.

Authors: K Yoshihara; T Hashida; Y Tanaka; H Ohgushi; H Yoshihara; T Kamiya
Journal: J Biol Chem Date: 1978-09-25 Impact factor: 5.157

5. Enzymatic synthesis of diadenosine tetraphosphate and diadenosine triphosphate with a purified lysyl-sRNA synthetase.

Authors: P C Zamecnik; M L Stephenson; C M Janeway; K Randerath
Journal: Biochem Biophys Res Commun Date: 1966-07-06 Impact factor: 3.575

6. Novel inhibitors of poly(ADP-ribose) synthetase.

Authors: M R Purnell; W J Whish
Journal: Biochem J Date: 1980-03-01 Impact factor: 3.857

7. HeLa cell DNA polymerase alpha is tightly associated with tryptophanyl-tRNA synthetase and diadenosine 5',5"'-P1,P4-tetraphosphate binding activities.

Authors: E Rapaport; P C Zamecnik; E F Baril
Journal: Proc Natl Acad Sci U S A Date: 1981-02 Impact factor: 11.205

Inhibition of ADP-ribosylation of histone H1 by analogs of diadenosine 5',5'''-p1,p4-tetraphosphate.

1. Bovine thymus poly(ADP-ribose) polymerase histone-dependent and Mg2+-dependent reaction.

2. Induction of sister chromatid exchanges by nicotinamide in Chinese hamster lung fibroblasts and human lymphoblastoid cells.

3. Interrelationship between poly (ADP-Rib) synthesis, intracellular NAD levels, and muscle or cartilage differentiation from mesodermal cells of embryonic chick limb.

4. Bovine thymus poly(adenosine diphosphate ribose) polymerase.

5. Enzymatic synthesis of diadenosine tetraphosphate and diadenosine triphosphate with a purified lysyl-sRNA synthetase.

6. Novel inhibitors of poly(ADP-ribose) synthetase.

7. HeLa cell DNA polymerase alpha is tightly associated with tryptophanyl-tRNA synthetase and diadenosine 5',5"'-P1,P4-tetraphosphate binding activities.

8. Poly (adnenosine diphosphoribose) synthase activity of isolated nuclei of normal and leukemic leukocytes.

9. Diadenosine 5',5'''-P1,P4-tetraphosphate, a ligand of the 57-kilodalton subunit of DNA polymerase alpha.

10. ADP-ribosylation of diadenosine 5',5"-P1,P4-tetraphosphate by poly(ADP-ribose) polymerase in vitro.

Review 1. Natural inhibitors of poly(ADP-ribose) polymerase-1.

Review 2. Inhibitors and activators of ADP-ribosylation reactions.