Literature DB >> 31085511

Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BacT/Alert or Bactec Resin-Containing Media in Simulated Adult Blood Cultures.

Teresa Spanu1,2, Brunella Posteraro3,4, Giulia Menchinelli1, Flora Marzia Liotti1, Liliana Giordano1, Giulia De Angelis1,2, Maurizio Sanguinetti5,2.   

Abstract

We assessed the antimicrobial-inactivation capability of BacT/Alert (FA Plus and FN Plus) or Bactec (Plus Aerobic/F and Plus Anaerobic/F) media for 40 antibiotic-bacterium combinations in simulated adult blood cultures. Aside from high recovery rates (93.2% and 88.4%, respectively), we showed that at the lowest but clinically relevant antibiotic concentrations, both BacT/Alert and Bactec media recovered all the organisms tested with drugs except for Escherichia coli, which was tested in the presence of meropenem. Delayed recoveries were mainly associated with vancomycin.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  blood culture system; drug inactivation; personalized therapy

Year:  2019        PMID： 31085511      PMCID： PMC6591622          DOI： 10.1128/AAC.00420-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  In vitro blood culture bottle inoculation of whole blood with clinically relevant antibiotic concentrations: a word of caution.

Authors:  M Grupper; J L Kuti; D P Nicolau
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2016-12-28       Impact factor: 3.267

2.  Neutralization of antimicrobial substances in new BacT/Alert FA and FN Plus blood culture bottles.

Authors:  Dieter Mitteregger; Wolfgang Barousch; Marion Nehr; Michael Kundi; Markus Zeitlinger; Athanasios Makristathis; Alexander M Hirschl
Journal:  J Clin Microbiol       Date:  2013-03-13       Impact factor: 5.948

3.  Antimicrobial binding and growth kinetics in BacT/ALERT® FA Plus and BACTEC® Aerobic/F Plus blood culture media.

Authors:  D Lovern; B Katzin; K Johnson; D Broadwell; E Miller; A Gates; P Deol; K Doing; A van Belkum; C Marshall; E Mathias; W M Dunne
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2016-09-10       Impact factor: 3.267

Review 4.  Blood culture-based diagnosis of bacteraemia: state of the art.

Authors:  O Opota; A Croxatto; G Prod'hom; G Greub
Journal:  Clin Microbiol Infect       Date:  2015-01-16       Impact factor: 8.067

5.  Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.

Authors:  Andrew Rhodes; Laura E Evans; Waleed Alhazzani; Mitchell M Levy; Massimo Antonelli; Ricard Ferrer; Anand Kumar; Jonathan E Sevransky; Charles L Sprung; Mark E Nunnally; Bram Rochwerg; Gordon D Rubenfeld; Derek C Angus; Djillali Annane; Richard J Beale; Geoffrey J Bellinghan; Gordon R Bernard; Jean-Daniel Chiche; Craig Coopersmith; Daniel P De Backer; Craig J French; Seitaro Fujishima; Herwig Gerlach; Jorge Luis Hidalgo; Steven M Hollenberg; Alan E Jones; Dilip R Karnad; Ruth M Kleinpell; Younsuk Koh; Thiago Costa Lisboa; Flavia R Machado; John J Marini; John C Marshall; John E Mazuski; Lauralyn A McIntyre; Anthony S McLean; Sangeeta Mehta; Rui P Moreno; John Myburgh; Paolo Navalesi; Osamu Nishida; Tiffany M Osborn; Anders Perner; Colleen M Plunkett; Marco Ranieri; Christa A Schorr; Maureen A Seckel; Christopher W Seymour; Lisa Shieh; Khalid A Shukri; Steven Q Simpson; Mervyn Singer; B Taylor Thompson; Sean R Townsend; Thomas Van der Poll; Jean-Louis Vincent; W Joost Wiersinga; Janice L Zimmerman; R Phillip Dellinger
Journal:  Intensive Care Med       Date:  2017-01-18       Impact factor: 17.440

6.  Comparison of BACTEC PLUS blood culture media to BacT/Alert FA blood culture media for detection of bacterial pathogens in samples containing therapeutic levels of antibiotics.

Authors:  Diane Flayhart; Anita P Borek; Teresa Wakefield; James Dick; Karen C Carroll
Journal:  J Clin Microbiol       Date:  2006-12-13       Impact factor: 5.948

7.  Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012.

Authors:  R Phillip Dellinger; Mitchell M Levy; Andrew Rhodes; Djillali Annane; Herwig Gerlach; Steven M Opal; Jonathan E Sevransky; Charles L Sprung; Ivor S Douglas; Roman Jaeschke; Tiffany M Osborn; Mark E Nunnally; Sean R Townsend; Konrad Reinhart; Ruth M Kleinpell; Derek C Angus; Clifford S Deutschman; Flavia R Machado; Gordon D Rubenfeld; Steven A Webb; Richard J Beale; Jean-Louis Vincent; Rui Moreno
Journal:  Crit Care Med       Date:  2013-02       Impact factor: 7.598

8.  Effects of Clinically Meaningful Concentrations of Antipseudomonal β-Lactams on Time to Detection and Organism Growth in Blood Culture Bottles.

Authors:  Mordechai Grupper; David P Nicolau; Jaber Aslanzadeh; Linda K Tanner; Joseph L Kuti
Journal:  J Clin Microbiol       Date:  2017-10-11       Impact factor: 5.948

Review 9.  How to Optimize the Use of Blood Cultures for the Diagnosis of Bloodstream Infections? A State-of-the Art.

Authors:  Brigitte Lamy; Sylvie Dargère; Maiken C Arendrup; Jean-Jacques Parienti; Pierre Tattevin
Journal:  Front Microbiol       Date:  2016-05-12       Impact factor: 5.640

10.  In vitro Evaluation of BACT/ALERT® VIRTUO®, BACT/ALERT 3D®, and BACTEC™ FX Automated Blood Culture Systems for Detection of Microbial Pathogens Using Simulated Human Blood Samples.

Authors:  Giulia Menchinelli; Flora Marzia Liotti; Barbara Fiori; Giulia De Angelis; Tiziana D'Inzeo; Liliana Giordano; Brunella Posteraro; Michela Sabbatucci; Maurizio Sanguinetti; Teresa Spanu
Journal:  Front Microbiol       Date:  2019-02-19       Impact factor: 5.640
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  5 in total

1.  Effect of Clinically Meaningful Antibiotic Concentrations on Recovery of Escherichia coli and Klebsiella pneumoniae Isolates from Anaerobic Blood Culture Bottles with and without Antibiotic Binding Resins.

Authors:  Iris H Chen; David P Nicolau; Joseph L Kuti
Journal:  J Clin Microbiol       Date:  2019-11-22       Impact factor: 5.948

2.  Recovery of Gram-Negative Bacteria from Aerobic Blood Culture Bottles Containing Antibiotic Binding Resins after Exposure to β-Lactam and Fluoroquinolone Concentrations.

Authors:  Iris H Chen; David P Nicolau; Joseph L Kuti
Journal:  J Clin Microbiol       Date:  2019-09-24       Impact factor: 5.948

3.  Inactivation of Clinically Frequently Used Antimicrobial Agents By BacT/ALERT FAN Plus and BACTEC Aerobic and Anaerobic Culture Media in Simulated Blood Cultures: First Comparative Evaluation in China Mainland.

Authors:  Xiuyu Xu; Qiang Wei; Zhu Wang; Jie Yan; Huijuan Wang; Yun Xia
Journal:  Infect Drug Resist       Date:  2021-01-19       Impact factor: 4.003

4.  Simulated Pediatric Blood Cultures to Assess the Inactivation of Clinically Relevant Antimicrobial Drug Concentrations in Resin-Containing Bottles.

Authors:  Liliana Giordano; Flora Marzia Liotti; Giulia Menchinelli; Giulia De Angelis; Tiziana D'Inzeo; Grazia Angela Morandotti; Maurizio Sanguinetti; Teresa Spanu; Brunella Posteraro
Journal:  Front Cell Infect Microbiol       Date:  2021-03-19       Impact factor: 5.293

5.  Blood Cultures for the Diagnosis of Infective Endocarditis: What Is the Benefit of Prolonged Incubation?

Authors:  Vincent Fihman; Hélène Faury; Amina Moussafeur; Raphaelle Huguet; Adrien Galy; Sébastien Gallien; Pascal Lim; Raphaël Lepeule; Paul-Louis Woerther
Journal:  J Clin Med       Date:  2021-12-13       Impact factor: 4.241
  5 in total

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