Literature DB >> 3108331

Cell surface expression of beta 2-microglobulin (beta 2m) correlates with stages of differentiation in B cell tumours.

R A Jones, C S Scott, D R Norfolk, A N Stark, J A Child.   

Abstract

Cell surface beta 2-microglobulin (beta 2m) densities of malignant B cells were determined by enzyme immunoassay in 97 cases of immunologically defined lymphoproliferative disease. Absolute beta 2m densities were found to depend on disease category with the lowest levels found on cells from chronic lymphocytic leukaemia (mean = 5.6 ng/10(6) cells, n = 27); atypical chronic lymphocytic leukaemia (mean = 5.9 ng/10(6) cells, n = 8); and prolymphocytoid chronic lymphocytic leukaemia variant (mean = 6.0 ng/10(6) cells, n = 16). beta 2m densities for B non-Hodgkin's lymphoma (n = 14) and B prolymphocytic leukaemia (n = 17) cases were 8.1 and 10.0 ng/10(6) cells, respectively, and the highest densities were found on cells from "late-B cell" tumours (mean = 14.3 ng/10(6) cells). Plasma cells from cases of Ig secreting tumours expressed unexpectedly low beta 2m densities (mean = 9.3 ng/10(6) cells; n = 6).

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Year:  1987        PMID： 3108331      PMCID： PMC1141008          DOI： 10.1136/jcp.40.5.486

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  29 in total

1.  Heavy chain of HLA-A and HLA-B antigens is conformationally labile: a possible role for beta 2-microglobulin.

Authors:  D Lancet; P Parham; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

Review 2.  MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.

Authors:  R M Zinkernagel; P C Doherty
Journal:  Adv Immunol       Date:  1979       Impact factor: 3.543

3.  Papain-solubilized HL-A antigens from cultured human lymphocytes contain two peptide fragments.

Authors:  P Cresswell; M J Turner; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1973-05       Impact factor: 11.205

4.  Use of a monoclonal antibody (W6/32) in structural studies of HLA-A,B,C, antigens.

Authors:  P Parham; C J Barnstable; W F Bodmer
Journal:  J Immunol       Date:  1979-07       Impact factor: 5.422

5.  Use of mitogens for the functional characteristization of human lymphocyte subpopulations with special reference to activation of human B lymphocytes by antibodies to beta2microglobulin.

Authors:  O Ringdén; E Möller
Journal:  Scand J Immunol       Date:  1976-06       Impact factor: 3.487

6.  Immunological identity of the small subunit of HL-A antigens and beta2-microglobulin and its turnover on the cell membrane.

Authors:  P Cresswell; T Springer; J L Strominger; M J Turner; H M Grey; R T Kubo
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205

7.  Highly purified papain-solubilized HL-A antigens contain beta2-microglobulin.

Authors:  P A Peterson; L Rask; J B Lindblom
Journal:  Proc Natl Acad Sci U S A       Date:  1974-01       Impact factor: 11.205

8.  Behaviour of serum beta 2-microglobulin and acute phase reactant proteins in chronic lymphocytic leukaemia. A multicentre study.

Authors:  B Späti; J A Child; S M Kerruish; E H Cooper
Journal:  Acta Haematol       Date:  1980       Impact factor: 2.195

9.  Association of the H-Y male antigen with beta2-microglobulin on human lymphoid and differentiated mouse teratocarcinoma cell lines.

Authors:  M Fellous; E Günther; R Kemler; J Wiels; R Berger; J L Guenet; H Jakob; F Jacob
Journal:  J Exp Med       Date:  1978-07-01       Impact factor: 14.307

10.  Misonidazole and MTDQ in combination: cytotoxic and radiosensitizing properties in hypoxic mammalian cells.

Authors:  M Astor; E J Hall
Journal:  Br J Cancer       Date:  1979-05       Impact factor: 7.640
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  2 in total

1.  Phenotypic switch from CD45RA+ to CD45RA- by normal blood T cells is associated with increased HLA-ABC expression for CD4+ and CD8+ populations but not for the NK-associated CD4-CD8dim+ or CD4-CD8- fractions.

Authors:  R A Jones; S J Richards; B E Roberts; J A Child; C S Scott
Journal:  Immunology       Date:  1990-05       Impact factor: 7.397

Review 2.  Prognostic factors in the non-Hodgkin's lymphomas--a time for consensus?

Authors:  J A Child
Journal:  Br J Cancer       Date:  1991-06       Impact factor: 7.640
  2 in total

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