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Literature DB >> 31082772

CREB1 induced lncRNA HAS2-AS1 promotes epithelial ovarian cancer proliferation and invasion via the miR-466/RUNX2 axis.

Lingling Tong¹, Yunyun Wang¹, Yu Ao¹, Xiaochun Sun².

Abstract

Accumulating evidence has indicated the vital roles of long noncoding RNA (lncRNA) in the epithelial ovarian cancer (EOC). However, the function of lncRNA HAS2-AS1 in EOC is still unclear. This study aims to investigate the expression and role of HAS2-AS1 in EOC. In the cells and tissue of EOC, HAS2-AS1 expression was markedly up-regulated. Besides, the overexpression of HAS2-AS1 indicated the poor clinical outcome of EOC patients. Transcription factor CREB1 could bind with the promoter of HAS2-AS1 and activate its transcriptional expression. Functionally, HAS2-AS1 knockdown suppressed the proliferation, invasion and tumor growth of EOC cells in vitro and in vivo. Mechanical investigation found that HAS2-AS1 could relive the RUNX2 protein expression via sponging the miR-466, acting as miRNA sponge. In conclusion, this finding suggests the CREB1/HAS2-AS1/miR-466/RUNX2 axis in the in the EOC tumorigenesis, providing the novel insight for the molecular mechanism of EOC.

Entities: Disease Gene Species

Keywords: CREB1; Epithelial ovarian cancer; HAS2-AS1; RUNX2; miR-466

Mesh：

Substances：

Year: 2019 PMID： 31082772 DOI： 10.1016/j.biopha.2019.108891

Source DB: PubMed Journal: Biomed Pharmacother ISSN： 0753-3322 Impact factor: 6.529

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Cited

16 in total

1. The Upregulation of HAS2-AS1 Relates to the Granulosa Cell Dysfunction by Repressing TGF-β Signaling and Upregulating HAS2.

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2. STAT3-Induced Upregulation of lncRNA CASC9 Promotes the Progression of Bladder Cancer by Interacting with EZH2 and Affecting the Expression of PTEN.

Authors: Bo Yuan; Rongqing Sun; Yuming Du; Zhankui Jia; Wencheng Yao; Jinjian Yang
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3. Long noncoding RNA HAS2-AS1 accelerates non-small cell lung cancer chemotherapy resistance by targeting LSD1/EphB3 pathway.

Authors: Peng Sun; Limin Sun; Jia Cui; Lili Liu; Qing He
Journal: Am J Transl Res Date: 2020-03-15 Impact factor: 4.060

4. HAS2-AS1 Acts as a Molecular Sponge for miR-137 and Promotes the Invasion and Migration of Glioma Cells by Targeting EZH2.

Authors: Juntong Wang; Yuyan Zhang; Aiwu You; Jun Li; Jingshun Gu; Guomin Rao; Xuehua Ge; Kun Zhang; Haoyu Fu; Xiaohui Liu; Jianfeng Li; Qianchao Wang; Xiaotang Wu; Ling Cheng; Mengjiao Zhu; Dongchun Wang
Journal: Cell Cycle Date: 2020-10-16 Impact factor: 4.534

CREB1 induced lncRNA HAS2-AS1 promotes epithelial ovarian cancer proliferation and invasion via the miR-466/RUNX2 axis.

1. The Upregulation of HAS2-AS1 Relates to the Granulosa Cell Dysfunction by Repressing TGF-β Signaling and Upregulating HAS2.

2. STAT3-Induced Upregulation of lncRNA CASC9 Promotes the Progression of Bladder Cancer by Interacting with EZH2 and Affecting the Expression of PTEN.

3. Long noncoding RNA HAS2-AS1 accelerates non-small cell lung cancer chemotherapy resistance by targeting LSD1/EphB3 pathway.

4. HAS2-AS1 Acts as a Molecular Sponge for miR-137 and Promotes the Invasion and Migration of Glioma Cells by Targeting EZH2.

Review 5. The Challenges and Opportunities of LncRNAs in Ovarian Cancer Research and Clinical Use.

Review 6. Cell Energy Metabolism and Hyaluronan Synthesis.

7. LncRNA HAS2-AS1 Promotes Glioblastoma Proliferation by Sponging miR-137.

8. Enhanced osteopontin splicing regulated by RUNX2 is HDAC-dependent and induces invasive phenotypes in NSCLC cells.

9. Identification of core differentially methylated genes in glioma.

Review 10. Exploring the Roles of lncRNAs in GBM Pathophysiology and Their Therapeutic Potential.