Janelle Tong1, Jack Phu1, Sieu K Khuu2, Nayuta Yoshioka1, Agnes Y Choi1, Lisa Nivison-Smith1, Robert E Marc3, Bryan W Jones3, Rebecca L Pfeiffer3, Michael Kalloniatis1, Barbara Zangerl4. 1. Centre for Eye Health, University of New South Wales, Sydney, New South Wales, Australia; School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia. 2. School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia. 3. Department of Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. 4. Centre for Eye Health, University of New South Wales, Sydney, New South Wales, Australia; School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia. Electronic address: b.zangerl@cfeh.com.au.
Abstract
PURPOSE: To develop location-specific models of normal, age-related changes in the macular ganglion cell layer (GCL) from optical coherence tomography (OCT). Using these OCT-derived models, we predicted visual field (VF) sensitivities and compared these results to actual VF sensitivities. DESIGN: Retrospective cohort study. METHODS: Single eyes of 254 normal participants were retrospectively enrolled from the Centre for Eye Health (Sydney, Australia). Macular GCL measurements were obtained using Spectralis OCT. Cluster algorithms were performed to identify spatial patterns demonstrating similar age-related change. Quadratic and linear regression models were subsequently used to characterize age-related GCL decline. Forty participants underwent additional testing with Humphrey VFs, and 95% prediction intervals were calculated to measure the predictive ability of structure-function models incorporating cluster-based pooling, age correction, and consideration of spatial summation. RESULTS: Quadratic GCL regression models provided a superior fit (P value <.0001-.0066), establishing that GCL decline commences in the late 30s across the macula. The equivalent linear rates of GCL decline showed eccentricity-dependent variation (0.13 μm/yr centrally vs 0.06 μm/yr peripherally); however, average, normalized GCL loss per year was consistent across the 64 macular measurement locations at 0.26%. The 95% prediction intervals describing predicted VF sensitivities were significantly narrower across all cluster-based structure-function models (3.79-4.99 dB) compared with models without clustering applied (5.66-6.73 dB, P < .0001). CONCLUSIONS: Combining spatial clustering with age-correction based on regression models allowed the development of robust models describing GCL changes with age. The resultant superior predictive ability of VF sensitivity from ganglion cell measurements may be applied to future models of disease development to improve detection of early macular GCL pathology.
PURPOSE: To develop location-specific models of normal, age-related changes in the macular ganglion cell layer (GCL) from optical coherence tomography (OCT). Using these OCT-derived models, we predicted visual field (VF) sensitivities and compared these results to actual VF sensitivities. DESIGN: Retrospective cohort study. METHODS: Single eyes of 254 normal participants were retrospectively enrolled from the Centre for Eye Health (Sydney, Australia). Macular GCL measurements were obtained using Spectralis OCT. Cluster algorithms were performed to identify spatial patterns demonstrating similar age-related change. Quadratic and linear regression models were subsequently used to characterize age-related GCL decline. Forty participants underwent additional testing with Humphrey VFs, and 95% prediction intervals were calculated to measure the predictive ability of structure-function models incorporating cluster-based pooling, age correction, and consideration of spatial summation. RESULTS: Quadratic GCL regression models provided a superior fit (P value <.0001-.0066), establishing that GCL decline commences in the late 30s across the macula. The equivalent linear rates of GCL decline showed eccentricity-dependent variation (0.13 μm/yr centrally vs 0.06 μm/yr peripherally); however, average, normalized GCL loss per year was consistent across the 64 macular measurement locations at 0.26%. The 95% prediction intervals describing predicted VF sensitivities were significantly narrower across all cluster-based structure-function models (3.79-4.99 dB) compared with models without clustering applied (5.66-6.73 dB, P < .0001). CONCLUSIONS: Combining spatial clustering with age-correction based on regression models allowed the development of robust models describing GCL changes with age. The resultant superior predictive ability of VF sensitivity from ganglion cell measurements may be applied to future models of disease development to improve detection of early macular GCL pathology.
Authors: Tony Redmond; Margarita B Zlatkova; David F Garway-Heath; Roger S Anderson Journal: Invest Ophthalmol Vis Sci Date: 2010-07-29 Impact factor: 4.799
Authors: Nazli Demirkaya; Hille W van Dijk; Sanne M van Schuppen; Michael D Abràmoff; Mona K Garvin; Milan Sonka; Reinier O Schlingemann; Frank D Verbraak Journal: Invest Ophthalmol Vis Sci Date: 2013-07-22 Impact factor: 4.799
Authors: Jack Phu; Sieu K Khuu; Michael Yapp; Nagi Assaad; Michael P Hennessy; Michael Kalloniatis Journal: Clin Exp Optom Date: 2017-06-22 Impact factor: 2.742
Authors: Nayuta Yoshioka; Barbara Zangerl; Lisa Nivison-Smith; Sieu K Khuu; Bryan W Jones; Rebecca L Pfeiffer; Robert E Marc; Michael Kalloniatis Journal: Invest Ophthalmol Vis Sci Date: 2017-06-01 Impact factor: 4.799
Authors: Janelle Tong; Jack Phu; David Alonso-Caneiro; Sieu K Khuu; Michael Kalloniatis Journal: Transl Vis Sci Technol Date: 2022-10-03 Impact factor: 3.048
Authors: Matt Trinh; Michael Kalloniatis; David Alonso-Caneiro; Lisa Nivison-Smith Journal: Invest Ophthalmol Vis Sci Date: 2022-05-02 Impact factor: 4.925
Authors: Moussa A Zouache; Alex Bennion; Jill L Hageman; Christian Pappas; Burt T Richards; Gregory S Hageman Journal: Sci Rep Date: 2020-12-03 Impact factor: 4.379
Authors: Janelle Tong; Jack Phu; David Alonso-Caneiro; Sieu K Khuu; Michael Kalloniatis Journal: Transl Vis Sci Technol Date: 2022-04-01 Impact factor: 3.048