Alireza Milajerdi1, Ammar Hassanzadeh Keshteli2, Hamid Afshar3, Ahmad Esmaillzadeh4, Peyman Adibi5. 1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran. 2. Department of Medicine, University of Alberta, Edmonton, Alberta, Canada; Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 3. Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. 4. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: esmaillzadeh@hlth.mui.ac.ir. 5. Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract
OBJECTIVES: Although several studies are available that link individual dietary antioxidants to the risk of psychological disorders, data about the association of dietary total antioxidant capacity (TAC) with depression and anxiety are scarce. This study was conducted to investigate the association between dietary TAC and odds of depression and anxiety among Iranian adults. METHODS: In this cross-sectional study, the dietary intakes of 3297 apparently healthy adults in the Isfahan province of Iran were assessed using a validated food-frequency questionnaire. Dietary TAC was estimated using the ferric-reducing antioxidant power international databases. Depression and anxiety were assessed using a validated Persian translated version of the Hospital Anxiety and Depression Scale questionnaire. Scores of 0 to 7 in either subscales of the questionnaire were considered normal, and scores of ≥8 indicated the presence of depression or anxiety. RESULTS: Overall, 943 study participants (28.6%) were depressed, and 448 participants (13.6%) had anxiety. After controlling for potential confounders, including the dietary intake of omega-3 fatty acids, we found that participants in the top quintile of the dietary TAC were 43% less likely to be depressed than those in the bottom category (odds ratio: 0.57; 95% confidence interval, 0.40-0.82; Ptrend = .001). Regarding anxiety, we found an inverse significant association between dietary TAC and anxiety when comparing the extreme quintiles (odds ratio: 0.62; 95% confidence interval, 0.39-0.99; Ptrend = .06). CONCLUSIONS: We found an significant inverse association between dietary TAC and odds of depression and anxiety among adults. Further prospective studies are required to confirm these findings.
OBJECTIVES: Although several studies are available that link individual dietary antioxidants to the risk of psychological disorders, data about the association of dietary total antioxidant capacity (TAC) with depression and anxiety are scarce. This study was conducted to investigate the association between dietary TAC and odds of depression and anxiety among Iranian adults. METHODS: In this cross-sectional study, the dietary intakes of 3297 apparently healthy adults in the Isfahan province of Iran were assessed using a validated food-frequency questionnaire. Dietary TAC was estimated using the ferric-reducing antioxidant power international databases. Depression and anxiety were assessed using a validated Persian translated version of the Hospital Anxiety and Depression Scale questionnaire. Scores of 0 to 7 in either subscales of the questionnaire were considered normal, and scores of ≥8 indicated the presence of depression or anxiety. RESULTS: Overall, 943 study participants (28.6%) were depressed, and 448 participants (13.6%) had anxiety. After controlling for potential confounders, including the dietary intake of omega-3 fatty acids, we found that participants in the top quintile of the dietary TAC were 43% less likely to be depressed than those in the bottom category (odds ratio: 0.57; 95% confidence interval, 0.40-0.82; Ptrend = .001). Regarding anxiety, we found an inverse significant association between dietary TAC and anxiety when comparing the extreme quintiles (odds ratio: 0.62; 95% confidence interval, 0.39-0.99; Ptrend = .06). CONCLUSIONS: We found an significant inverse association between dietary TAC and odds of depression and anxiety among adults. Further prospective studies are required to confirm these findings.
Authors: Gabriela Amorim Pereira; Alessandra da Silva; Helen Hermana M Hermsdorff; Ana Paula Boroni Moreira; Aline Silva de Aguiar Journal: J Clin Transl Res Date: 2021-09-27