| Literature DB >> 31077279 |
Marie-Astrid Hoogerwerf1, Luc E Coffeng2, Eric A T Brienen1, Jacqueline J Janse1, Marijke C C Langenberg1, Yvonne C M Kruize1, Chelsea Gootjes1, Mikhael D Manurung1, Mark Dekker1, Luke Becker3, Marianne A A Erkens4, Martha T van der Beek4, Munisha S Ganesh1, Carola Feijt1, Beatrice M F Winkel1, Inge M Westra5, Pauline Meij5, Alex Loukas3, Leo G Visser6, Sake J de Vlas2, Maria Yazdanbakhsh1, Lisette van Lieshout1, Meta Roestenberg1,6.
Abstract
Four healthy volunteers were infected with 50 Necator americanus infective larvae (L3) in a controlled human hookworm infection trial and followed for 52 weeks. The kinetics of fecal egg counts in volunteers was assessed with Bayesian multilevel analysis, which revealed an increase between weeks 7 and 13, followed by an egg density plateau of about 1000 eggs/g of feces. Variation in egg counts was minimal between same-day measurements but varied considerably between days, particularly during the plateau phase. These analyses pave the way for the controlled human hookworm model to accelerate drug and vaccine efficacy studies.Entities:
Keywords: Bayesian statistics; controlled human infection; hookworm; vaccine development
Mesh：
Year: 2019 PMID： 31077279 DOI： 10.1093/infdis/jiz218
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226