M Witte1, D Thaçi2. 1. Klinik für Dermatologie, UKSH Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Deutschland. mareike.witte@uksh.de. 2. Klinik für Dermatologie, UKSH Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Deutschland.
Abstract
BACKGROUND: Psoriasis is a frequent chronic inflammatory systemic disease. It is associated with changes in the microbiome, which may trigger psoriasis and influence the course of the disease. OBJECTIVE: Current methods for detection and the potential role of the microbiome in the pathogenesis of psoriasis are described. MATERIAL AND METHODS: A literature search was conducted using the databases Medline and PubMed as well as a general internet and book research. RESULTS: Both skin and gut microbiota are involved in the immunopathogenesis and may substantially modulate psoriasis. Antimicrobial peptides may serve as a link between the microbiome and the immunological mechanisms in psoriasis by regulating the microbiome at interfaces and can trigger psoriasis as antigens. Recent innovative methods, such as 16S rRNA next-generation sequencing significantly facilitate microbiome analysis. CONCLUSION: The analysis of the microbiome in patients with psoriasis before, during and after treatment provides a basis for the identification of potential biomarkers for predicting individual treatment responses and facilitating the decision for a certain treatment.
BACKGROUND:Psoriasis is a frequent chronic inflammatory systemic disease. It is associated with changes in the microbiome, which may trigger psoriasis and influence the course of the disease. OBJECTIVE: Current methods for detection and the potential role of the microbiome in the pathogenesis of psoriasis are described. MATERIAL AND METHODS: A literature search was conducted using the databases Medline and PubMed as well as a general internet and book research. RESULTS: Both skin and gut microbiota are involved in the immunopathogenesis and may substantially modulate psoriasis. Antimicrobial peptides may serve as a link between the microbiome and the immunological mechanisms in psoriasis by regulating the microbiome at interfaces and can trigger psoriasis as antigens. Recent innovative methods, such as 16S rRNA next-generation sequencing significantly facilitate microbiome analysis. CONCLUSION: The analysis of the microbiome in patients with psoriasis before, during and after treatment provides a basis for the identification of potential biomarkers for predicting individual treatment responses and facilitating the decision for a certain treatment.
Authors: Peck Y Ong; Takaaki Ohtake; Corinne Brandt; Ian Strickland; Mark Boguniewicz; Tomas Ganz; Richard L Gallo; Donald Y M Leung Journal: N Engl J Med Date: 2002-10-10 Impact factor: 91.245