Claudia Hülpüsch1,2,3, Matthias Reiger4,5. 1. Institut für Umweltmedizin, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764, München, Deutschland. Claudia.huelpuesch@tum.de. 2. Lehrstuhl für Umweltmedizin, Medizinische Fakultät Augsburg, Universität Augsburg, Neusäßer Str. 47, 86156, Augsburg, Deutschland. Claudia.huelpuesch@tum.de. 3. Lehrstuhl für Umweltmedizin, Technische Universität München, Ismaninger Str. 22, 81675, München, Deutschland. Claudia.huelpuesch@tum.de. 4. Institut für Umweltmedizin, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764, München, Deutschland. Matthias.reiger@uni-a.de. 5. Lehrstuhl für Umweltmedizin, Medizinische Fakultät Augsburg, Universität Augsburg, Neusäßer Str. 47, 86156, Augsburg, Deutschland. Matthias.reiger@uni-a.de.
Abstract
BACKGROUND: Our skin is a very important and complex organ of the body. The microorganisms of the skin, the so-called microbiome, represent an important part of the healthy skin barrier and are influenced by various external and internal factors. AIM: The question to what extent the skin microbiome represents a diagnostic or even therapeutic target in the context of skin diseases is discussed. MATERIALS AND METHODS: A literature search was performed. RESULTS: Several diseases are associated with negative alterations of the skin microbiome. In atopic dermatitis, a correlation between severity and increased availability of Staphylococcus aureus is known, with a loss of bacterial diversity on the skin. In the future, S. aureus will not only be used as a diagnostic marker in atopic dermatitis, but also represents a promising target as a predictive marker for therapeutic success. The role of the skin microbiome in psoriasis has not yet been researched in depth. However, there is evidence that dysbiosis of the skin microbiome contributes to the course of psoriasis and that there is a disturbance in immune tolerance in patients. In the case of acne, the involvement of Cutibacterium acnes in the clinical picture is well known; however, recent findings show that it is not sufficient to identify the species, but certain characteristics of C. acnes strains are associated. CONCLUSION: Microbial biomarkers are currently only established in atopic dermatitis. For other diseases, this might be the case in the future; however combinations of microorganisms, single species and also strains with specific characteristics must be considered.
BACKGROUND: Our skin is a very important and complex organ of the body. The microorganisms of the skin, the so-called microbiome, represent an important part of the healthy skin barrier and are influenced by various external and internal factors. AIM: The question to what extent the skin microbiome represents a diagnostic or even therapeutic target in the context of skin diseases is discussed. MATERIALS AND METHODS: A literature search was performed. RESULTS: Several diseases are associated with negative alterations of the skin microbiome. In atopic dermatitis, a correlation between severity and increased availability of Staphylococcus aureus is known, with a loss of bacterial diversity on the skin. In the future, S. aureus will not only be used as a diagnostic marker in atopic dermatitis, but also represents a promising target as a predictive marker for therapeutic success. The role of the skin microbiome in psoriasis has not yet been researched in depth. However, there is evidence that dysbiosis of the skin microbiome contributes to the course of psoriasis and that there is a disturbance in immune tolerance in patients. In the case of acne, the involvement of Cutibacterium acnes in the clinical picture is well known; however, recent findings show that it is not sufficient to identify the species, but certain characteristics of C. acnes strains are associated. CONCLUSION: Microbial biomarkers are currently only established in atopic dermatitis. For other diseases, this might be the case in the future; however combinations of microorganisms, single species and also strains with specific characteristics must be considered.
Authors: Chris Callewaert; Frederiek-Maarten Kerckhof; Michael S Granitsiotis; Mireille Van Gele; Tom Van de Wiele; Nico Boon Journal: PLoS One Date: 2013-08-12 Impact factor: 3.240
Authors: Hye-Jin Kim; Jin Ju Kim; Nu Ri Myeong; Taeyune Kim; DooA Kim; Susun An; Hanbyul Kim; Taehun Park; Sue Im Jang; Jae Ho Yeon; Ilyoung Kwack; Woo Jun Sul Journal: Sci Rep Date: 2019-11-14 Impact factor: 4.379