Literature DB >> 31076548

Overcoming the Blood-Brain Barrier with an Implantable Ultrasound Device.

Adam M Sonabend1, Roger Stupp2.   

Abstract

Ultrasound-based blood-brain barrier disruption enhances drug delivery. To bypass the human skull, an implantable ultrasound emitter was developed, and proven safe and feasible in a first-in-human trial. Next development steps aim for larger field of disruption, quantification of drug levels, use of various drugs, and ultimately a pivotal trial demonstrating improved outcome.See related article by Idbaih et al., p. 3793. ©2019 American Association for Cancer Research.

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Year:  2019        PMID： 31076548      PMCID： PMC7057332          DOI： 10.1158/1078-0432.CCR-19-0932

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  5 in total

1.  MRI-guided disruption of the blood-brain barrier using transcranial focused ultrasound in a rat model.

Authors:  Meaghan A O'Reilly; Adam C Waspe; Rajiv Chopra; Kullervo Hynynen
Journal:  J Vis Exp       Date:  2012-03-13       Impact factor: 1.355

2.  Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma.

Authors:  Lisa H Treat; Nathan McDannold; Yongzhi Zhang; Natalia Vykhodtseva; Kullervo Hynynen
Journal:  Ultrasound Med Biol       Date:  2012-07-19       Impact factor: 2.998

3.  Safety and Feasibility of Repeated and Transient Blood-Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma.

Authors:  Ahmed Idbaih; Michael Canney; Lisa Belin; Carole Desseaux; Alexandre Vignot; Guillaume Bouchoux; Nicolas Asquier; Bruno Law-Ye; Delphine Leclercq; Anne Bissery; Yann De Rycke; Clementine Trosch; Laurent Capelle; Marc Sanson; Khe Hoang-Xuan; Caroline Dehais; Caroline Houillier; Florence Laigle-Donadey; Bertrand Mathon; Arthur André; Cyril Lafon; Jean-Yves Chapelon; Jean-Yves Delattre; Alexandre Carpentier
Journal:  Clin Cancer Res       Date:  2019-03-19       Impact factor: 12.531

4.  MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits.

Authors:  Nathan McDannold; Natalia Vykhodtseva; Scott Raymond; Ferenc A Jolesz; Kullervo Hynynen
Journal:  Ultrasound Med Biol       Date:  2005-11       Impact factor: 2.998

5.  Clinical trial of blood-brain barrier disruption by pulsed ultrasound.

Authors:  Alexandre Carpentier; Michael Canney; Alexandre Vignot; Vincent Reina; Kevin Beccaria; Catherine Horodyckid; Carine Karachi; Delphine Leclercq; Cyril Lafon; Jean-Yves Chapelon; Laurent Capelle; Philippe Cornu; Marc Sanson; Khê Hoang-Xuan; Jean-Yves Delattre; Ahmed Idbaih
Journal:  Sci Transl Med       Date:  2016-06-15       Impact factor: 17.956
  5 in total
  8 in total

1.  Ultrasound-mediated Delivery of Paclitaxel for Glioma: A Comparative Study of Distribution, Toxicity, and Efficacy of Albumin-bound Versus Cremophor Formulations.

Authors:  Daniel Y Zhang; Crismita Dmello; Li Chen; Victor A Arrieta; Edgar Gonzalez-Buendia; J Robert Kane; Lisa P Magnusson; Aneta Baran; C David James; Craig Horbinski; Alexandre Carpentier; Carole Desseaux; Michael Canney; Miguel Muzzio; Roger Stupp; Adam M Sonabend
Journal:  Clin Cancer Res       Date:  2019-12-12       Impact factor: 12.531

2.  Essential oils for blood-brain barrier disruption: Preclinical studies of NEO100 in breast cancer brain metastases.

Authors:  Rimas V Lukas
Journal:  Neuro Oncol       Date:  2021-10-01       Impact factor: 13.029

3.  Ribosomal protein S11 influences glioma response to TOP2 poisons.

Authors:  Chidiebere U Awah; Li Chen; Mukesh Bansal; Aayushi Mahajan; Jan Winter; Meeki Lad; Louisa Warnke; Edgar Gonzalez-Buendia; Cheol Park; Daniel Zhang; Eric Feldstein; Dou Yu; Markella Zannikou; Irina V Balyasnikova; Regina Martuscello; Silvana Konerman; Balázs Győrffy; Kirsten B Burdett; Denise M Scholtens; Roger Stupp; Atique Ahmed; Patrick Hsu; Adam M Sonabend
Journal:  Oncogene       Date:  2020-06-11       Impact factor: 9.867

4.  Chemically-Gated and Sustained Molecular Transport through Nanoporous Gold Thin Films in Biofouling Conditions.

Authors:  Barath Palanisamy; Noah Goshi; Erkin Seker
Journal:  Nanomaterials (Basel)       Date:  2021-02-16       Impact factor: 5.076

5.  Ultrasound-mediated blood-brain barrier opening increases cell-free DNA in a time-dependent manner.

Authors:  Daniel Y Zhang; Andrew Gould; Hannah C Happ; Mark W Youngblood; Crismita Dmello; Seong Jae Kang; Michael Canney; Roger Stupp; Gemma L Carvill; Adam M Sonabend
Journal:  Neurooncol Adv       Date:  2021-11-12

Review 6.  "Focused Ultrasound-mediated Drug Delivery in Humans - a Path Towards Translation in Neurodegenerative Diseases".

Authors:  Joanna M Wasielewska; Anthony R White
Journal:  Pharm Res       Date:  2022-03-07       Impact factor: 4.200

7.  Neratinib and Capecitabine for the Treatment of Leptomeningeal Metastases from HER2-Positive Breast Cancer: A Series in the Setting of a Compassionate Program.

Authors:  Alessia Pellerino; Riccardo Soffietti; Francesco Bruno; Roberta Manna; Erminia Muscolino; Pierangela Botta; Rosa Palmiero; Roberta Rudà
Journal:  Cancers (Basel)       Date:  2022-02-25       Impact factor: 6.639

8.  Exploiting Focused Ultrasound to Aid Intranasal Drug Delivery for Brain Therapy.

Authors:  Gaetano Barbato; Robert Nisticò; Viviana Triaca
Journal:  Front Pharmacol       Date:  2022-04-14       Impact factor: 5.988
  8 in total

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