Stephanie Menghini-Müller1, Erich Studerus25, Sarah Ittig25, Ulrike Heitz2, Laura Egloff2, Christina Andreou2, Lucia R Valmaggia16, Matthew J Kempton15, Mark van der Gaag18, Lieuwe de Haan17, Barnaby Nelson23, Neus Barrantes-Vidal28, Merete Nordentoft33, Stephan Ruhrmann10, Gabriele Sachs36, Bart P Rutten36, Jim van Os38, Anita Riecher-Rössler25, Philip McGuire15, Lucia R Valmaggia16, Matthew J Kempton15, Maria Calem15, Stefania Tognin15, Gemma Modinos15, Lieuwe de Haan17, Mark van der Gaag18, Eva Velthorst19, Tamar C Kraan20, Daniella S van Dam21, Nadine Burger22, Barnaby Nelson23, Patrick McGorry23, G Paul Amminger23, Christos Pantelis24, Athena Politis23, Joanne Goodall23, Anita Riecher-Rössler25, Stefan Borgwardt25, Charlotte Rapp25, Sarah Ittig25, Erich Studerus25, Renata Smieskova25, Rodrigo Bressan26, Ary Gadelha26, Elisa Brietzke27, Graccielle Asevedo26, Elson Asevedo26, Andre Zugman26, Neus Barrantes-Vidal28, Tecelli Domínguez-Martínez29, Anna Racioppi30, Paula Cristóbal-Narváez30, Thomas R Kwapil31, Manel Monsonet30, Mathilde Kazes32, Claire Daban32, Julie Bourgin32, Olivier Gay32, Célia Mam-Lam-Fook32, Marie-Odile Krebs32, Dorte Nordholm33, Lasse Randers33, Kristine Krakauer33, Louise Glenthøj33, Birte Glenthøj34, Merete Nordentoft33, Stephan Ruhrmann10, Dominika Gebhard10, Julia Arnhold35, Joachim Klosterkötter10, Gabriele Sachs36, Iris Lasser36, Bernadette Winklbaur36, Philippe A Delespaul37, Bart P Rutten36, Jim van Os38. 1. Center for Gender Research and Early Detection, University of Basel Psychiatric Hospital, Basel, Switzerland; University of Basel, Department of Psychology, Division of Clinical Psychology and Epidemiology, Basel, Switzerland. 2. Center for Gender Research and Early Detection, University of Basel Psychiatric Hospital, Basel, Switzerland. 3. Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom. 4. Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom. 5. VU University, Faculty of Behavioural and Movement Sciences, Department of Clinical Psychology and EMGO+ Institute for Health Care Research, Amsterdam, the Netherlands; Parnassia Psychiatric Institute, Department of Psychosis Research, The Hague, the Netherlands. 6. AMC, Academic Psychiatric Centre, Department Early Psychosis, Amsterdam, the Netherlands; Arkin, Amsterdam, the Netherlands. 7. Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia. 8. Departament de Psicologia Clínica I de la Salut (Universitat Autònoma de Barcelona), Fundació Sanitària Sant Pere Claver (Spain), Spanish Mental Health Research Network (CIBERSAM), Spain. 9. Mental Health Center Copenhagen, Mental Health Services in the Capital Region of Denmark, Denmark; Institute for Clinical Medicine, Faculty of Health Science, University of Copenhagen, Denmark. 10. Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany. 11. Medical University of Vienna, Department of Psychiatry and Psychotherapy, Austria. 12. Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht, the Netherlands. 13. Department Psychiatry, Brain Centre Rudolf Magnus, Utrecht University Medical Centre, Utrecht, the Netherlands; Department of Psychiatry and Psychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University Medical Centre, Maastricht, the Netherlands; King's College London, King's Health Partners Department of Psychosis Studies, Institute of Psychiatry, London, United Kingdom. 14. Center for Gender Research and Early Detection, University of Basel Psychiatric Hospital, Basel, Switzerland. Electronic address: anita.riecher@upk.ch. 15. Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, Denmark 458 Hill, SE5 8AF London, United Kingdom. 16. Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, Denmark Hill, 456 SE5 8AF London, United Kingdom. 17. Amsterdam UMC, University of Amsterdam, Psychiatry, Department Early Psychosis, Meibergdreef 9, Amsterdam, The Netherlands; Arkin Amsterdam. 18. VU University, Faculty of Behavioural and Movement Sciences, Department of Clinical Psychology and Amsterdam Public Mental Health research institute, van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands; Mental Health Institute Noord-Holland Noord, Hoorn, The Netherlands; Parnassia Psychiatric Institute, Department of Psychosis Research, Zoutkeetsingel 40, 2512 HNThe Hague, The Netherlands. 19. Department of Psychiatry and Seaver Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, NY, US; Early Psychosis Section, Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. 20. Mental Health Institute Arkin, Amsterdam, The Netherlands. 21. Amsterdam UMC, University of Amsterdam, Psychiatry, Department Early Psychosis, Meibergdreef 9, Amsterdam, The Netherlands. 22. Arkin Amsterdam. 23. Orygen, The National Centre of Excellence in Youth Mental Health, University of Melbourne; Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road (Locked Bag 10), Parkville, Victoria 485 3052, Australia. 24. Melbourne Neuropsychiatry Centre, The University of Melbourne. 25. University Psychiatric Hospital, Wilhelm Klein-Strasse 27, CH-4002 Basel, Switzerland. 26. LiNC - Lab Interdisciplinar Neurociôncias Clínicas, Depto Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo - UNIFESP. 27. Depto Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo - UNIFESP. 28. Departament de Psicologia Clínica i de la Salut (Universitat Autònoma de Barcelona), Fundació Sanitària Sant Pere Claver (Spain), Spanish Mental Health Research Network (CIBERSAM). 29. CONACYT-Dirección de Investigaciones Epidemiológicas y Psicosociales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (México). 30. Departament de Psicologia Clínica i de la Salut (Universitat Autònoma de Barcelona). 31. Department of Psychology, University of Illinois at Urbana-Champaign (USA). 32. University Paris Descartes, Hôpital Sainte-Anne, C'JAAD, Service Hospitalo-Universitaire, Inserm U894, Institut de Psychiatrie (CNRS 3557) Paris, France. 33. Mental Health Center Copenhagen and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Center Glostrup, Mental Health Services in the Capital Region of Copenhagen, University of Copenhagen. 34. Centre for Neuropsychiatric Schizophrenia Research (CNSR) & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark. 35. Psyberlin, Berlin, Germany. 36. Medical University of Vienna, Department of Psychiatry and Psychotherapy. 37. Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, P.O. Box 616, 6200 MD 464 Maastricht, The Netherlands; Mondriaan Mental Health Trust, P.O. Box 4436 CX Heerlen, The Netherlands. 38. Medical University of Vienna, Department of Psychiatry and Psychotherapy; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, Denmark 458 Hill, SE5 8AF London, United Kingdom.
Abstract
BACKGROUND: Gender differences in symptomatology in chronic schizophrenia and first episode psychosis patients have often been reported. However, little is known about gender differences in those at risk of psychotic disorders. This study investigated gender differences in symptomatology, drug use, comorbidity (i.e. substance use, affective and anxiety disorders) and global functioning in patients with an at-risk mental state (ARMS) for psychosis. METHODS: The sample consisted of 336 ARMS patients (159 women) from the prodromal work package of the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI; 11 centers). Clinical symptoms, drug use, comorbidity and functioning were assessed at first presentation to an early detection center using structured interviews. RESULTS: In unadjusted analyses, men were found to have significantly higher rates of negative symptoms and current cannabis use while women showed higher rates of general psychopathology and more often displayed comorbid affective and anxiety disorders. No gender differences were found for global functioning. The results generally did not change when corrected for possible cofounders (e.g. cannabis use). However, most differences did not withstand correction for multiple testing. CONCLUSIONS: Findings indicate that gender differences in symptomatology and comorbidity in ARMS are similar to those seen in overt psychosis and in healthy controls. However, observed differences are small and would only be reliably detected in studies with high statistical power. Moreover, such small effects would likely not be clinically meaningful.
BACKGROUND: Gender differences in symptomatology in chronic schizophrenia and first episode psychosispatients have often been reported. However, little is known about gender differences in those at risk of psychotic disorders. This study investigated gender differences in symptomatology, drug use, comorbidity (i.e. substance use, affective and anxiety disorders) and global functioning in patients with an at-risk mental state (ARMS) for psychosis. METHODS: The sample consisted of 336 ARMS patients (159 women) from the prodromal work package of the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI; 11 centers). Clinical symptoms, drug use, comorbidity and functioning were assessed at first presentation to an early detection center using structured interviews. RESULTS: In unadjusted analyses, men were found to have significantly higher rates of negative symptoms and current cannabis use while women showed higher rates of general psychopathology and more often displayed comorbid affective and anxiety disorders. No gender differences were found for global functioning. The results generally did not change when corrected for possible cofounders (e.g. cannabis use). However, most differences did not withstand correction for multiple testing. CONCLUSIONS: Findings indicate that gender differences in symptomatology and comorbidity in ARMS are similar to those seen in overt psychosis and in healthy controls. However, observed differences are small and would only be reliably detected in studies with high statistical power. Moreover, such small effects would likely not be clinically meaningful.
Authors: Heleen S van der Heijden; Frederike Schirmbeck; Matthew J Kempton; Mark van der Gaag; Kelly Allott; Barnaby Nelson; Stephan Ruhrmann; Lieuwe de Haan; Jentien M Vermeulen Journal: Eur Psychiatry Date: 2021-09-21 Impact factor: 5.361
Authors: Frederike Schirmbeck; Nadine C van der Burg; Matthijs Blankers; Jentien M Vermeulen; Philip McGuire; Lucia R Valmaggia; Matthew J Kempton; Mark van der Gaag; Anita Riecher-Rössler; Rodrigo A Bressan; Neus Barrantes-Vidal; Barnaby Nelson; G Paul Amminger; Patrick McGorry; Christos Pantelis; Marie-Odile Krebs; Stephan Ruhrmann; Gabriele Sachs; Bart P F Rutten; Jim van Os; Merete Nordentoft; Birte Glenthøj; Paolo Fusar-Poli; Lieuwe de Haan Journal: Schizophr Bull Date: 2022-01-21 Impact factor: 9.306
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Authors: Alexandre González-Rodríguez; Mary V Seeman; Alexandre Díaz-Pons; Rosa Ayesa-Arriola; Mentxu Natividad; Eva Calvo; José A Monreal Journal: J Clin Med Date: 2022-08-04 Impact factor: 4.964
Authors: Óscar Soto-Angona; Gerard Anmella; María José Valdés-Florido; Nieves De Uribe-Viloria; Andre F Carvalho; Brenda W J H Penninx; Michael Berk Journal: BMC Med Date: 2020-10-01 Impact factor: 8.775
Authors: Marianna Mazza; Emanuele Caroppo; Domenico De Berardis; Giuseppe Marano; Carla Avallone; Georgios D Kotzalidis; Delfina Janiri; Lorenzo Moccia; Alessio Simonetti; Eliana Conte; Giovanni Martinotti; Luigi Janiri; Gabriele Sani Journal: J Pers Med Date: 2021-12-02