| Literature DB >> 31073405 |
Giacomo Biagiotti1,2, Federica Pisaneschi2, Seth T Gammon2, Fabrizio Machetti1,3, Maria Cristina Ligi1,3, Giuliano Giambastiani3,4, Giulia Tuci1,3, Emily Powell5, Helen Piwnica-Worms5, Erica Pranzini6, Paolo Paoli6, Stefano Cicchi1,3, David Piwnica-Worms2.
Abstract
A drug delivery system (DDS) for combined therapy, based on a short oxidized multiwalled carbon nanotube, is reported. It was prepared exploiting a synthetic approach which allowed loading of two drugs, doxorubicin and metformin, the targeting agent biotin and a radiolabeling tag, to enable labeling with Ga-68 or Cu-64 in order to perform an extensive biodistribution study by PET/CT. The DDS biodistribution profile changes with different administration methods. Once administered at therapeutic doses, the DDS showed a marginal beneficial effect on 4T1 tumor bearing mice, a syngeneic and orthotopic model of triple negative breast cancer, with survival extended by 1 week and 2 days in 20% of the mice. This is encouraging given the aggressiveness of the 4T1 tumor. Furthermore our DDS was well tolerated, ruling out concerns regarding the toxicity of carbon nanotubes.Entities:
Keywords: 4T1 tumor cells; PET imaging; carbon nanotube; combined therapy; doxorubicin; metformin
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Year: 2019 PMID： 31073405 PMCID： PMC6501563 DOI： 10.1039/C8TB03299H
Source DB: PubMed Journal: J Mater Chem B ISSN： 2050-750X Impact factor: 6.331