Literature DB >> 28423924

Advances in siRNA delivery in cancer therapy.

Aishwarya Singh1, Piyush Trivedi1, Narendra Kumar Jain1.   

Abstract

RNA interference (RNAi)-based therapeutic approaches are under vibrant scrutinisation to seek cancer cure. siRNA suppress expression of the carcinogenic genes by targeting the mRNA expression. However, in vivo systemic siRNA therapy is hampered by the barriers such as poor cellular uptake, instability under physiological conditions, off-target effects and possible immunogenicity. To overcome these challenges, systemic siRNA therapy warrants the development of clinically suitable, safe, and effective drug delivery systems. Herein, we review the barriers, potential siRNA drug delivery systems, and application of siRNA in clinical trials for cancer therapy. Further research is required to harness the full potential of siRNA as a cancer therapeutic.

Entities:  

Keywords:  Cancer therapy; RNA interference; biological barriers; gene silencing; siRNA

Mesh：

Substances：

Year:  2017        PMID： 28423924     DOI： 10.1080/21691401.2017.1307210

Source DB:  PubMed          Journal:  Artif Cells Nanomed Biotechnol        ISSN： 2169-1401            Impact factor:   5.678


  60 in total

1.  VHH characterization. Comparison of recombinant with chemically synthesized anti-HER2 VHH.

Authors:  Lucie Hartmann; Thomas Botzanowski; Mathieu Galibert; Magali Jullian; Eric Chabrol; Gabrielle Zeder-Lutz; Valérie Kugler; Johann Stojko; Jean-Marc Strub; Gilles Ferry; Lukasz Frankiewicz; Karine Puget; Renaud Wagner; Sarah Cianférani; Jean A Boutin
Journal:  Protein Sci       Date:  2019-08-29       Impact factor: 6.725

2.  Evaluation of siRNA Stability and Interaction with Serum Components Using an Agarose Gel-Based Single-Molecule FRET Labeling Method.

Authors:  Martina Tuttolomondo; Henrik J Ditzel
Journal:  Methods Mol Biol       Date:  2021

Review 3.  Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges.

Authors:  John D Martin; Horacio Cabral; Triantafyllos Stylianopoulos; Rakesh K Jain
Journal:  Nat Rev Clin Oncol       Date:  2020-02-07       Impact factor: 66.675

4.  Simple FRET Electrophoresis Method for Precise and Dynamic Evaluation of Serum siRNA Stability.

Authors:  Martina Tuttolomondo; Henrik J Ditzel
Journal:  ACS Med Chem Lett       Date:  2020-01-17       Impact factor: 4.345

5.  Multiwalled Carbon Nanotubes for Combination Therapy: a Biodistribution and Efficacy Pilot Study.

Authors:  Giacomo Biagiotti; Federica Pisaneschi; Seth T Gammon; Fabrizio Machetti; Maria Cristina Ligi; Giuliano Giambastiani; Giulia Tuci; Emily Powell; Helen Piwnica-Worms; Erica Pranzini; Paolo Paoli; Stefano Cicchi; David Piwnica-Worms
Journal:  J Mater Chem B       Date:  2019-03-12       Impact factor: 6.331

6.  Enhancer RNA AL928768.3 from the IGH Locus Regulates MYC Expression and Controls the Proliferation and Chemoresistance of Burkitt Lymphoma Cells with IGH/MYC Translocation.

Authors:  Ekaterina Mikhailovna Stasevich; Aksinya Nicolaevna Uvarova; Matvey Mikhailovich Murashko; Elmira Ramilevna Khabusheva; Saveliy Andreevich Sheetikov; Vladimir Sergeyevich Prassolov; Dmitriy Vladimirovich Kuprash; Denis Eriksonovich Demin; Anton Markovich Schwartz
Journal:  Int J Mol Sci       Date:  2022-04-21       Impact factor: 6.208

Review 7.  Innovative approaches for treatment of osteosarcoma.

Authors:  Emel Rothzerg; Abigail L Pfaff; Sulev Koks
Journal:  Exp Biol Med (Maywood)       Date:  2022-01-19

Review 8.  Epigenetics of colorectal cancer: biomarker and therapeutic potential.

Authors:  Gerhard Jung; Eva Hernández-Illán; Leticia Moreira; Francesc Balaguer; Ajay Goel
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2020-01-03       Impact factor: 46.802

9.  DDAB cationic lipid-mPEG, PCL copolymer hybrid nano-carrier synthesis and application for delivery of siRNA targeting IGF-1R into breast cancer cells.

Authors:  M Khodaei; K Rostamizadeh; A H Taromchi; H Monirinasab; M Fathi
Journal:  Clin Transl Oncol       Date:  2021-01-03       Impact factor: 3.405

Review 10.  Twenty Years of Research on Cyclodextrin Conjugates with PAMAM Dendrimers.

Authors:  Hidetoshi Arima
Journal:  Pharmaceutics       Date:  2021-05-11       Impact factor: 6.321
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