Literature DB >> 31065968

A causal proportional hazards estimator under homogeneous or heterogeneous selection in an IV setting.

Ditte Nørbo Sørensen1, Torben Martinussen2, Eric Tchetgen Tchetgen3.   

Abstract

In this paper we present a framework to do estimation in a structural Cox model when there may be unobserved confounding. The model is phrased in terms of a selection bias function and a baseline model that describes how covariates affect the survival time in a scenario without exposure. In this way model congeniality is ensured. The method uses an instrumental variable. Interestingly, the formulated model turns out to have similarities to the so-called Cox-Aalen survival model for the observed data. We exploit this to enhance estimation of the unknown parameters. This also allows us to derive large sample properties of the proposed estimator.

Entities:  

Keywords:  Causal effect; Instrumental variable; Selection bias function; Structural Cox model; Treatment effect on the treated

Mesh:

Year:  2019        PMID: 31065968     DOI: 10.1007/s10985-019-09476-y

Source DB:  PubMed          Journal:  Lifetime Data Anal        ISSN: 1380-7870            Impact factor:   1.588


  12 in total

1.  A causal proportional hazards estimator for the effect of treatment actually received in a randomized trial with all-or-nothing compliance.

Authors:  T Loeys; E Goetghebeur
Journal:  Biometrics       Date:  2003-03       Impact factor: 2.571

2.  Instruments for causal inference: an epidemiologist's dream?

Authors:  Miguel A Hernán; James M Robins
Journal:  Epidemiology       Date:  2006-07       Impact factor: 4.822

3.  Attributable fraction functions for censored event times.

Authors:  Li Chen; D Y Lin; Donglin Zeng
Journal:  Biometrika       Date:  2010-05-28       Impact factor: 2.445

4.  A linear regression model for the analysis of life times.

Authors:  O O Aalen
Journal:  Stat Med       Date:  1989-08       Impact factor: 2.373

5.  Instrumental variables estimation under a structural Cox model.

Authors:  Torben Martinussen; Ditte Nørbo Sørensen; Stijn Vansteelandt
Journal:  Biostatistics       Date:  2019-01-01       Impact factor: 5.899

6.  Instrumental variables estimation of exposure effects on a time-to-event endpoint using structural cumulative survival models.

Authors:  Torben Martinussen; Stijn Vansteelandt; Eric J Tchetgen Tchetgen; David M Zucker
Journal:  Biometrics       Date:  2017-05-10       Impact factor: 2.571

7.  Instrumental variable estimation in a survival context.

Authors:  Eric J Tchetgen Tchetgen; Stefan Walter; Stijn Vansteelandt; Torben Martinussen; Maria Glymour
Journal:  Epidemiology       Date:  2015-05       Impact factor: 4.822

8.  Using instrumental variables to estimate a Cox's proportional hazards regression subject to additive confounding.

Authors:  Todd A MacKenzie; Tor D Tosteson; Nancy E Morden; Therese A Stukel; A James O'Malley
Journal:  Health Serv Outcomes Res Methodol       Date:  2014-06

9.  Identification of causal effects on binary outcomes using structural mean models.

Authors:  Paul S Clarke; Frank Windmeijer
Journal:  Biostatistics       Date:  2010-06-03       Impact factor: 5.899

10.  The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach.

Authors:  Børge G Nordestgaard; Tom M Palmer; Marianne Benn; Jeppe Zacho; Anne Tybjaerg-Hansen; George Davey Smith; Nicholas J Timpson
Journal:  PLoS Med       Date:  2012-05-01       Impact factor: 11.069

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