| Literature DB >> 31065968 |
Ditte Nørbo Sørensen1, Torben Martinussen2, Eric Tchetgen Tchetgen3.
Abstract
In this paper we present a framework to do estimation in a structural Cox model when there may be unobserved confounding. The model is phrased in terms of a selection bias function and a baseline model that describes how covariates affect the survival time in a scenario without exposure. In this way model congeniality is ensured. The method uses an instrumental variable. Interestingly, the formulated model turns out to have similarities to the so-called Cox-Aalen survival model for the observed data. We exploit this to enhance estimation of the unknown parameters. This also allows us to derive large sample properties of the proposed estimator.Entities:
Keywords: Causal effect; Instrumental variable; Selection bias function; Structural Cox model; Treatment effect on the treated
Mesh:
Year: 2019 PMID: 31065968 DOI: 10.1007/s10985-019-09476-y
Source DB: PubMed Journal: Lifetime Data Anal ISSN: 1380-7870 Impact factor: 1.588