INTRODUCTION: Gram negative bacilli are the important causes of common clinical infections. Carbapenem resistant Enterobacteriaceae are considered as important public health threat and is classified as urgent by the Centers of Disease Control and Prevention because of their progressive geographic dissemination and limited therapeutic alternatives. This study was done to find out the resistance pattern of Carbapenem among Enterobacteriaceae. METHODS: The descriptive cross-sectional study was carried out in Clinical Microbiology laboratory from February 2018 to May 2018 after ethical approval. Organism was identified on the basis of its microscopic observation by performing Gram's stain and by identification of morphology after its growth in culture media followed by its biochemical reactions. Antibiotic sensitivity test of isolated pathogens was done using Muller Hinton Agar by the standard disk diffusion technique of Kirby-Bauer method. RESULTS: In our study, total 1055 sample belongs to the family Enterobacteriaceae. From the family Enterobactericeae, 348 (27%) of the bacilli were found to be Carbapenem resistant. Among which most common bacteria was Klebsiella pneumoniae followed by Escherichia coli. All strains of Carbapenem resistant Enterobacteriaceae were sensitive to Colistin, Polymyxin B and Tigecycline. CONCLUSIONS: Among Enterobacteriaceae, around one-third of the bacterial isolates were Carbapenem resistant. However, to reduce drug resistance antimicrobial stewardship programme and proper infection control measures is required.
INTRODUCTION: Gram negative bacilli are the important causes of common clinical infections. Carbapenem resistant Enterobacteriaceae are considered as important public health threat and is classified as urgent by the Centers of Disease Control and Prevention because of their progressive geographic dissemination and limited therapeutic alternatives. This study was done to find out the resistance pattern of Carbapenem among Enterobacteriaceae. METHODS: The descriptive cross-sectional study was carried out in Clinical Microbiology laboratory from February 2018 to May 2018 after ethical approval. Organism was identified on the basis of its microscopic observation by performing Gram's stain and by identification of morphology after its growth in culture media followed by its biochemical reactions. Antibiotic sensitivity test of isolated pathogens was done using Muller Hinton Agar by the standard disk diffusion technique of Kirby-Bauer method. RESULTS: In our study, total 1055 sample belongs to the family Enterobacteriaceae. From the family Enterobactericeae, 348 (27%) of the bacilli were found to be Carbapenem resistant. Among which most common bacteria was Klebsiella pneumoniae followed by Escherichia coli. All strains of Carbapenem resistant Enterobacteriaceae were sensitive to Colistin, Polymyxin B and Tigecycline. CONCLUSIONS: Among Enterobacteriaceae, around one-third of the bacterial isolates were Carbapenem resistant. However, to reduce drug resistance antimicrobial stewardship programme and proper infection control measures is required.
Authors: Vinícius Victor Lorenzoni; Danielly da Costa Silva; Roberta Filipini Rampelotto; Patrícia Chaves Brites; Bárbara Villa; Rosmari Hörner Journal: Rev Soc Bras Med Trop Date: 2017 Sep-Oct Impact factor: 1.581
Authors: Ryan S Arnold; Kerri A Thom; Saarika Sharma; Michael Phillips; J Kristie Johnson; Daniel J Morgan Journal: South Med J Date: 2011-01 Impact factor: 0.954
Authors: Pedro Torres-Gonzalez; Miguel Enrique Cervera-Hernandez; María Dolores Niembro-Ortega; Francisco Leal-Vega; Luis Pablo Cruz-Hervert; Lourdes García-García; Arturo Galindo-Fraga; Areli Martinez-Gamboa; Miriam Bobadilla-Del Valle; Jose Sifuentes-Osornio; Alfredo Ponce-de-Leon Journal: PLoS One Date: 2015-10-02 Impact factor: 3.240