Literature DB >> 31062146

Can perforations of descemet's window (DW) improve the outcome of canaloplasty in open angle glaucoma?

Barbara Pullig1, Norbert Josef Koerber2, Thomas Dietlein3.   

Abstract

PURPOSE: This study evaluates whether additional opening of the descemet's window (DW) in canaloplasty has a positive effect on the intraocular pressure (IOP), glaucoma medication, visual acuity and postoperative complications and further interventions within the subsequent 12 months. This study also compares the difference of myopia and non-myopia based on the respective surgical method, as well as the quality of life after surgery by means of a questionnaire. PATIENTS AND METHODS: This retrospective study included 114 patients who had a complete ophthalmic examination at baseline, as well as the first post-operative day and at 1, 3, 6, and 12 months following the procedure. The patients were divided into three groups: group 1 with intact DW (n = 35), group 2 with accidental rupture of the DW (n = 40), and group 3 with scheduled puncture of the DW (n = 39). Main outcome parameters were IOP reduction and the number of IOP-lowering medications. Intraoperative and postoperative complications were documented systematically.
RESULTS: With a follow-up period of 12 months, all three groups showed statistically significant reductions in mean IOP and number of glaucoma medications as compared with preoperative values. At 12 months, group 1 (group 2/3) had a mean IOP reduction of 27.3% (33.1%/36.3%) and medication use reduction of 75% (82.6%/91.7%). Comparing the three surgical groups, there was no significant difference in terms of reduction of IOP and medication (p > 0.05) at all time points. Surgical complications were similarly rare. The number of subconjunctival blebs was statistically significantly different in the three groups (p < 0.05; group 1, 0%; group 2, 15%; group 3, 12.8%). Only in group 1, a revision after surgery was necessary in three cases. A significant difference concerning IOP, medication use, and visual acuity was not found between myopic eyes and non-myopic eyes after canaloplasty. The postop-surgical questionnaire showed that with 90.5% in group 1, 88.5% in group 2, and with 90.5% in group 3, the patients were highly satisfied with the results of surgery.
CONCLUSION: The intraoperative scheduled puncture of the DW in tendency showed better but no statistically significant results after 1 year regarding lowering of the IOP, the visual acuity, and postoperative medication usage. In addition, no increased risk of complications was observed in the myopic eye after the opening of the DW.

Entities:  

Keywords:  Canaloplasty; Glaucoma surgery; Non-perforating surgery; Quality of life

Mesh:

Year:  2019        PMID: 31062146     DOI: 10.1007/s00417-019-04340-z

Source DB:  PubMed          Journal:  Graefes Arch Clin Exp Ophthalmol        ISSN: 0721-832X            Impact factor:   3.117


  21 in total

1.  Canaloplasty in one eye compared with viscocanalostomy in the contralateral eye in patients with bilateral open-angle glaucoma.

Authors:  Norbert Josef Koerber
Journal:  J Glaucoma       Date:  2012-02       Impact factor: 2.503

2.  Primary viscocanalostomy versus trabeculectomy for primary open-angle glaucoma: three-year prospective randomized clinical trial.

Authors:  Ilgaz Sagdic Yalvac; Mehmet Sahin; Umit Eksioglu; Inci Kocak Midillioglu; Bekir Sitki Aslan; Sunay Duman
Journal:  J Cataract Refract Surg       Date:  2004-10       Impact factor: 3.351

3.  Canaloplasty: Three-year results of circumferential viscodilation and tensioning of Schlemm canal using a microcatheter to treat open-angle glaucoma.

Authors:  Richard A Lewis; Kurt von Wolff; Manfred Tetz; Norbert Koerber; John R Kearney; Bradford J Shingleton; Thomas W Samuelson
Journal:  J Cataract Refract Surg       Date:  2011-04       Impact factor: 3.351

4.  The clinical validity of the treatment satisfaction survey for intraocular pressure in ocular hypertensive and glaucoma patients.

Authors:  D G Day; E D Sharpe; M J Atkinson; J A Stewart; W C Stewart
Journal:  Eye (Lond)       Date:  2006-05       Impact factor: 3.775

5.  Structural and ultrastructural changes to the sclera in a mammalian model of high myopia.

Authors:  N A McBrien; L M Cornell; A Gentle
Journal:  Invest Ophthalmol Vis Sci       Date:  2001-09       Impact factor: 4.799

6.  [Canaloplasty and transient anterior chamber haemorrhage: a prognostic factor?].

Authors:  J M Koch; A Heiligenhaus; C Heinz
Journal:  Klin Monbl Augenheilkd       Date:  2010-11-16       Impact factor: 0.700

7.  [Midterm patient satisfaction following mitomycin C-assisted trabeculectomy].

Authors:  A M Schild; J F Jordan; W Konen; G K Krieglstein; T S Dietlein
Journal:  Klin Monbl Augenheilkd       Date:  2008-02       Impact factor: 0.700

8.  Canaloplasty: circumferential viscodilation and tensioning of Schlemm canal using a flexible microcatheter for the treatment of open-angle glaucoma in adults: two-year interim clinical study results.

Authors:  Richard A Lewis; Kurt von Wolff; Manfred Tetz; Norbert Koerber; John R Kearney; Bradford J Shingleton; Thomas W Samuelson
Journal:  J Cataract Refract Surg       Date:  2009-05       Impact factor: 3.351

9.  Canaloplasty: circumferential viscodilation and tensioning of Schlemm's canal using a flexible microcatheter for the treatment of open-angle glaucoma in adults: interim clinical study analysis.

Authors:  Richard A Lewis; Kurt von Wolff; Manfred Tetz; Norbert Korber; John R Kearney; Bradford Shingleton; Thomas W Samuelson
Journal:  J Cataract Refract Surg       Date:  2007-07       Impact factor: 3.351

10.  Risk factors for hypotony maculopathy.

Authors:  Lilia A Fannin; Joyce C Schiffman; Donald L Budenz
Journal:  Ophthalmology       Date:  2003-06       Impact factor: 12.079

View more
  1 in total

1.  Modified suture-assisted canaloplasty in Asians with primary open-angle glaucoma: a prospective study with 12-month follow-up.

Authors:  Ya Liang; Qiuli Yu; Hong Sun; Liuwei Gu; Zhilan Yuan
Journal:  BMC Ophthalmol       Date:  2022-05-04       Impact factor: 2.086

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.