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Literature DB >> 31061542

Short Enantioselective Formal Synthesis of (-)-Platencin.

Christian Defieber¹, Justin T Mohr^1,2, Gennadii A Grabovyi², Brian M Stoltz¹.

Abstract

A short enantioselective formal synthesis of the antibiotic natural product platencin is reported. Key steps in the synthesis include enantioselective decarboxylation alkylation, aldehyde/olefin radical cyclization, and regioselective aldol cyclization.

Entities: Chemical Disease Gene

Keywords: Formal synthesis; alkylation; enantioconvergent; enantioselective; palladium

Year: 2018 PMID： 31061542 PMCID： PMC6498846 DOI： 10.1055/s-0037-1610437

Source DB: PubMed Journal: Synthesis (Stuttg) ISSN： 0039-7881 Impact factor: 3.157

65 in total

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6. Thiol-catalyzed acyl radical cyclization of alkenals.

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7. Intramolecular conjugate addition of alkenyl and aryl functions to enones initiated by lithium-iodine exchange.

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Review 8. Phosphinooxazolines--a new class of versatile, modular P,N-ligands for asymmetric catalysis.

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9. Synthesis and biochemical evaluation of phosphonoformate oligodeoxyribonucleotides.

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10. Platensimycin is a selective FabF inhibitor with potent antibiotic properties.

Authors: Jun Wang; Stephen M Soisson; Katherine Young; Wesley Shoop; Srinivas Kodali; Andrew Galgoci; Ronald Painter; Gopalakrishnan Parthasarathy; Yui S Tang; Richard Cummings; Sookhee Ha; Karen Dorso; Mary Motyl; Hiranthi Jayasuriya; John Ondeyka; Kithsiri Herath; Chaowei Zhang; Lorraine Hernandez; John Allocco; Angela Basilio; José R Tormo; Olga Genilloud; Francisca Vicente; Fernando Pelaez; Lawrence Colwell; Sang Ho Lee; Bruce Michael; Thomas Felcetto; Charles Gill; Lynn L Silver; Jeffery D Hermes; Ken Bartizal; John Barrett; Dennis Schmatz; Joseph W Becker; Doris Cully; Sheo B Singh
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Review 2. The Allylic Alkylation of Ketone Enolates.

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