Joseph Cafone1, Peter Capucilli1, David A Hill1,2, Jonathan M Spergel1,2. 1. Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia. 2. Department of Pediatrics, Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Abstract
PURPOSE OF REVIEW: The aim of this review is to discuss the current evidence regarding the development of eosinophilic esophagitis (EoE) in individuals undergoing oral and sublingual immunotherapy (SLIT) for both food and environmental allergens. Cumulative incidence of EoE in patients on allergen immunotherapy for peanut, milk, and egg is estimated. RECENT FINDINGS: De novo development of EoE in patients undergoing oral and SLIT has been demonstrated on the scale of case reports and prospective randomized trials. However, few individuals with EoE-like symptoms during immunotherapy undergo endoscopy, and the long-term outcomes of immunotherapy-associated EoE are unknown. SUMMARY: Evidence exists to suggest that allergen immunotherapy could place individuals at risk for the development of EoE, the true incidence of which may vary depending on antigen exposure and methods used to define the condition.
PURPOSE OF REVIEW: The aim of this review is to discuss the current evidence regarding the development of eosinophilic esophagitis (EoE) in individuals undergoing oral and sublingual immunotherapy (SLIT) for both food and environmental allergens. Cumulative incidence of EoE in patients on allergen immunotherapy for peanut, milk, and egg is estimated. RECENT FINDINGS: De novo development of EoE in patients undergoing oral and SLIT has been demonstrated on the scale of case reports and prospective randomized trials. However, few individuals with EoE-like symptoms during immunotherapy undergo endoscopy, and the long-term outcomes of immunotherapy-associated EoE are unknown. SUMMARY: Evidence exists to suggest that allergen immunotherapy could place individuals at risk for the development of EoE, the true incidence of which may vary depending on antigen exposure and methods used to define the condition.
Authors: Jesus R Guajardo; Lauren M Plotnick; Jennifer M Fende; Margaret H Collins; Philip E Putnam; Marc E Rothenberg Journal: J Pediatr Date: 2002-10 Impact factor: 4.406
Authors: Chris A Liacouras; Jonathan M Spergel; Eduardo Ruchelli; Ritu Verma; Maria Mascarenhas; Edisio Semeao; Jonathan Flick; Janice Kelly; Terry Brown-Whitehorn; Petar Mamula; Jonathan E Markowitz Journal: Clin Gastroenterol Hepatol Date: 2005-12 Impact factor: 11.382
Authors: Gordon H Guyatt; Andrew D Oxman; Gunn E Vist; Regina Kunz; Yngve Falck-Ytter; Pablo Alonso-Coello; Holger J Schünemann Journal: BMJ Date: 2008-04-26
Authors: Ernesto Enrique; Fernando Pineda; Tamim Malek; Joan Bartra; María Basagaña; Raquel Tella; José Vicente Castelló; Rosario Alonso; José Antonio de Mateo; Teresa Cerdá-Trias; María del Mar San Miguel-Moncín; Susana Monzón; María García; Ricardo Palacios; Anna Cisteró-Bahíma Journal: J Allergy Clin Immunol Date: 2005-10-03 Impact factor: 10.793
Authors: F J Moawad; G R Veerappan; J M Lake; C L Maydonovitch; B R Haymore; S E Kosisky; R K H Wong Journal: Aliment Pharmacol Ther Date: 2009-11-19 Impact factor: 8.171
Authors: Cristina Almansa; Murli Krishna; Anna M Buchner; Marwan S Ghabril; Nicholas Talley; Kenneth R DeVault; Herbert Wolfsen; Massimo Raimondo; Juan C Guarderas; Sami R Achem Journal: Am J Gastroenterol Date: 2009-02-24 Impact factor: 10.864
Authors: Philipp Schreiner; Luc Biedermann; Thomas Greuter; Benjamin L Wright; Alex Straumann Journal: Dis Esophagus Date: 2021-01-11 Impact factor: 3.429
Authors: Duncan M Morgan; Bert Ruiter; Neal P Smith; Ang A Tu; Brinda Monian; Brandon E Stone; Navneet Virk-Hundal; Qian Yuan; Wayne G Shreffler; J Christopher Love Journal: Sci Immunol Date: 2021-08-13
Authors: Julianna Dilollo; Eric M Rodríguez-López; Leah Wilkey; Elizabeth K Martin; Jonathan M Spergel; David A Hill Journal: Allergy Date: 2021-05-14 Impact factor: 13.146
Authors: Miguel Gonzalez-Visiedo; Xin Li; Maite Munoz-Melero; Michael D Kulis; Henry Daniell; David M Markusic Journal: Mol Ther Methods Clin Dev Date: 2022-07-16 Impact factor: 5.849
Authors: Martina Votto; Gian Luigi Marseglia; Maria De Filippo; Ilaria Brambilla; Silvia Maria Elena Caimmi; Amelia Licari Journal: Front Pediatr Date: 2020-05-29 Impact factor: 3.418