[Treatment of renal cell carcinoma invading the inferior vena cava; role of preoperative targeting chemotherapy].

Locally invasive carcinoma of the kidney, prognosis of which still remains unsatisfactory, is a therapeutic challenge in uro-oncology. Our recent experience has indicated that mitomycin C microcapsule therapy which is introduced as a prototype of intravascular targeting chemotherapy is an effective preoperative adjuvant in terms of improving the prognosis of locally invasive kidney carcinoma. Two cases with huge kidney carcinoma directly invading into the caval wall were presented. They were initially considered inoperable, but repeated microcapsule therapy for 5 months provided substantial tumor reduction and facilitated radical operation. The patients are tumor-free at 2 and 8 year after the treatment respectively. The role of targeting chemotherapy in the treatment of locally invasive carcinoma was discussed.