Heather Lazarow1, Michele Nicolo2, Charlene Compher3, Colleen R Kucharczuk4, Edward A Stadtmauer5, Daniel J Landsburg5. 1. Hospital of the University of Pennsylvania, Philadelphia, PA. Electronic address: Heather.Lazarow@uphs.upenn.edu. 2. University of Southern California, Los Angeles, CA. 3. University of Pennsylvania, School of Nursing, Philadelphia, PA. 4. Hospital of the University of Pennsylvania, Philadelphia, PA. 5. Abramson Cancer Center, Hospital of the University of Pennsylvania, Philadelphia, PA.
Abstract
INTRODUCTION: Autologous stem cell transplantation (ASCT) patients are at risk for malnutrition before transplantation admission as well as malnutrition acquired during their transplantation admission. PATIENTS AND METHODS: In this retrospective, observational study we examined data related to consecutive adults (n = 330) admitted for ASCT between 2014 and 2016 at the Hospital of the University of Pennsylvania. Malnutrition risk on admission (identified by the Malnutrition Screening Tool) and transplantation-associated weight loss were analyzed for independent associations with hospital length of stay, nosocomial infection, intensive care unit transfer, deconditioning, time to platelet and neutrophil engraftment, 30-day readmission, and 1-year mortality. RESULTS: Adults with high malnutrition risk (n = 60) had a longer median hospital stay (P = .004), longer median time to platelet engraftment (P = .022), increased nosocomial infections (P = .047), and increased 1-year mortality (P = .036). Adults with high transplantation-associated weight loss (n = 100) experienced longer hospital stays (P < .001) and more intensive care unit transfers (P = .001). Outcomes for deconditioning, time to neutrophil engraftment, and 30-day readmission did not differ significantly on the basis of nutrition risk or weight loss. CONCLUSION: Further research is needed to determine whether early nutrition intervention would improve these outcomes.
INTRODUCTION: Autologous stem cell transplantation (ASCT) patients are at risk for malnutrition before transplantation admission as well as malnutrition acquired during their transplantation admission. PATIENTS AND METHODS: In this retrospective, observational study we examined data related to consecutive adults (n = 330) admitted for ASCT between 2014 and 2016 at the Hospital of the University of Pennsylvania. Malnutrition risk on admission (identified by the Malnutrition Screening Tool) and transplantation-associated weight loss were analyzed for independent associations with hospital length of stay, nosocomial infection, intensive care unit transfer, deconditioning, time to platelet and neutrophil engraftment, 30-day readmission, and 1-year mortality. RESULTS: Adults with high malnutrition risk (n = 60) had a longer median hospital stay (P = .004), longer median time to platelet engraftment (P = .022), increased nosocomial infections (P = .047), and increased 1-year mortality (P = .036). Adults with high transplantation-associated weight loss (n = 100) experienced longer hospital stays (P < .001) and more intensive care unit transfers (P = .001). Outcomes for deconditioning, time to neutrophil engraftment, and 30-day readmission did not differ significantly on the basis of nutrition risk or weight loss. CONCLUSION: Further research is needed to determine whether early nutrition intervention would improve these outcomes.
Authors: Zachary A K Frosch; Esin C Namoglu; Nandita Mitra; Daniel J Landsburg; Sunita D Nasta; Justin E Bekelman; Raghuram Iyengar; Carmen E Guerra; Marilyn M Schapira Journal: JCO Oncol Pract Date: 2021-09-15