Literature DB >> 3105317

Recombination between the factor VIII gene and the DXS52 locus gives the most probable genetic order as centromere-fra(X)-DXS15-DXS52-F8C-telomere.

L M Mulligan, H J Grover, V S Blanchette, A R Giles, D P Lillicrap, A Phillips, J J Holden, B N White.   

Abstract

The linkage relationship between the factor VIII gene (F8C) and the DXS52 locus was examined in 8 families. Two recombinations were identified in 35 informative meioses (Zmax = 5.67; theta = 0.05), one in a family with hemophilia A, the other in a family with the fra(X) syndrome. Based on the latter recombination, the most probable order of loci was determined to be centromere-fra(X)-DXS15-DXS52-F8C-telomere. When these data are added to those reported previously the most probable genetic distance between F8C and DXS52 is 3 cM (Z = 14.62). Identification of these and other recombinations suggests that the use of DXS52 as a genetic marker for carrier detection and prenatal diagnosis of hemophilia A has an error rate between 3-5%.

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Year:  1987        PMID： 3105317     DOI： 10.1002/ajmg.1320260334

Source DB:  PubMed          Journal:  Am J Med Genet        ISSN： 0148-7299


  8 in total

1.  Further localization of X-linked hydrocephalus in the chromosomal region Xq28.

Authors:  P J Willems; L Vits; P Raeymaekers; J Beuten; P Coucke; J J Holden; C Van Broeckhoven; S T Warren; M Sagi; D Robinson
Journal:  Am J Hum Genet       Date:  1992-08       Impact factor: 11.025

2.  Multilocus analysis of the fragile X syndrome.

Authors:  W T Brown; A Gross; C Chan; E C Jenkins; J L Mandel; I Oberlé; B Arveiler; G Novelli; S Thibodeau; R Hagerman
Journal:  Hum Genet       Date:  1988-03       Impact factor: 4.132

3.  A contiguous, 3-Mb physical map of Xq28 extending from the colorblindness locus to DXS15.

Authors:  S Kenwrick; J Gitschier
Journal:  Am J Hum Genet       Date:  1989-12       Impact factor: 11.025

4.  Nephrogenic diabetes insipidus: close linkage with markers from the distal long arm of the human X chromosome.

Authors:  N Knoers; H van der Heyden; B A van Oost; H H Ropers; L Monnens; J Willems
Journal:  Hum Genet       Date:  1988-09       Impact factor: 4.132

5.  Linkage analysis of families with fragile-X mental retardation, using a novel RFLP marker (DXS 304).

Authors:  N Dahl; P Goonewardena; H Malmgren; K H Gustavson; G Holmgren; E Seemanova; G Annerén; A Flood; U Pettersson
Journal:  Am J Hum Genet       Date:  1989-08       Impact factor: 11.025

6.  X-linked nephrogenic diabetes insipidus: from the ship Hopewell to RFLP studies.

Authors:  D G Bichet; G N Hendy; M Lonergan; M F Arthus; S Ligier; Z Pausova; R Kluge; H Zingg; P Saenger; E Oppenheimer
Journal:  Am J Hum Genet       Date:  1992-11       Impact factor: 11.025

7.  A HindIII RFLP and a gene lesion in the coagulation factor VIII gene.

Authors:  F Bernardi; C Legnani; S Volinia; P Patracchini; G Rodorigo; V DeRosa; G Marchetti
Journal:  Hum Genet       Date:  1988-04       Impact factor: 4.132

8.  Mapping of the locus for X-linked cardioskeletal myopathy with neutropenia and abnormal mitochondria (Barth syndrome) to Xq28.

Authors:  P A Bolhuis; G W Hensels; T J Hulsebos; F Baas; P G Barth
Journal:  Am J Hum Genet       Date:  1991-03       Impact factor: 11.025
  8 in total

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