Tom Norris1, Sara E Ramel2, Patrick Catalano3, Carol Ni Caoimh4, Paola Roggero5, Deirdre Murray6, David A Fields7, Ellen W Demerath8, William Johnson1. 1. School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. 2. Division of Neonatology, School of Medicine, University of Minnesota, Minneapolis, MN. 3. Maternal Infant Research Institute, Tufts University School of Medicine, Friedman School of Nutrition Science and Policy, Boston, MA. 4. Irish Centre for Fetal and Neonatal Translational Research (INFANT) Centre, University College Cork, Cork, Ireland. 5. Neonatal Intensive Care Unit, Department of Clinical Science and Community Health, Fondazione I.R.C.C.S. "Ca' Granda" Ospedale Maggiore Policlinico, University of Milan, Milan, Italy. 6. Departments of Paediatrics and Child Health, University College Cork, Cork, Ireland. 7. Department of Pediatrics, University of Oklahoma Health Sciences Center and CMRI Metabolic Research Program, Oklahoma City, OK. 8. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Abstract
BACKGROUND: Air-displacement plethysmography (ADP) is a good candidate for monitoring body composition in newborns and young infants, but reference centile curves are lacking that allow for assessment at birth and across the first 6 mo of life. OBJECTIVE: Using pooled data from 4 studies, we aimed to produce new charts for assessment according to gestational age at birth (30 + 1 to 41 + 6 wk) and postnatal age at measurement (1-27 wk). METHODS: The sample comprised 222 preterm infants born in the United States who were measured at birth; 1029 term infants born in Ireland who were measured at birth; and 149 term infants born in the United States and 57 term infants born in Italy who were measured at birth, 1 and 2 wk, and 1, 2, 3, 4, 5, and 6 mo of age. Infants whose birth weights were <3rd or >97th centile of the INTERGROWTH-21st standard were excluded, thereby ensuring that the charts depict body composition of infants whose birth weights did not indicate suboptimal fetal growth. Sex-specific centiles for fat mass (kg), fat-free mass (kg), and percentage body fat were estimated using the lambda-mu-sigma (LMS) method. RESULTS: For each sex and measure (e.g., fat mass), the new charts comprised 2 panels. The first showed centiles according to gestational age, allowing term infants to be assessed at birth and preterm infants to be monitored until they reached term. The second showed centiles according to postnatal age, allowing all infants to be monitored to age 27 wk. The LMS values underlying the charts were presented, enabling researchers and clinicians to convert measurements to centiles and z scores. CONCLUSIONS: The new charts provide a single tool for the assessment of body composition, according to ADP, in infants across the first 6 mo of life and will help enhance early-life nutritional management.
BACKGROUND: Air-displacement plethysmography (ADP) is a good candidate for monitoring body composition in newborns and young infants, but reference centile curves are lacking that allow for assessment at birth and across the first 6 mo of life. OBJECTIVE: Using pooled data from 4 studies, we aimed to produce new charts for assessment according to gestational age at birth (30 + 1 to 41 + 6 wk) and postnatal age at measurement (1-27 wk). METHODS: The sample comprised 222 preterm infants born in the United States who were measured at birth; 1029 term infants born in Ireland who were measured at birth; and 149 term infants born in the United States and 57 term infants born in Italy who were measured at birth, 1 and 2 wk, and 1, 2, 3, 4, 5, and 6 mo of age. Infants whose birth weights were <3rd or >97th centile of the INTERGROWTH-21st standard were excluded, thereby ensuring that the charts depict body composition of infants whose birth weights did not indicate suboptimal fetal growth. Sex-specific centiles for fat mass (kg), fat-free mass (kg), and percentage body fat were estimated using the lambda-mu-sigma (LMS) method. RESULTS: For each sex and measure (e.g., fat mass), the new charts comprised 2 panels. The first showed centiles according to gestational age, allowing term infants to be assessed at birth and preterm infants to be monitored until they reached term. The second showed centiles according to postnatal age, allowing all infants to be monitored to age 27 wk. The LMS values underlying the charts were presented, enabling researchers and clinicians to convert measurements to centiles and z scores. CONCLUSIONS: The new charts provide a single tool for the assessment of body composition, according to ADP, in infants across the first 6 mo of life and will help enhance early-life nutritional management.
Authors: Katherine A Bell; Sara E Ramel; Daniel T Robinson; Carol L Wagner; Brian Scottoline; Mandy B Belfort Journal: J Perinatol Date: 2022-10-06 Impact factor: 3.225
Authors: Efrah I Yousuf; Niels Rochow; Jenifer Li; Julia Simioni; Elizabeth Gunn; Eileen K Hutton; Katherine M Morrison Journal: Pediatr Res Date: 2022-03-16 Impact factor: 3.953
Authors: Ariel A Salas; Colm P Travers; Maggie L Jerome; Paula Chandler-Laney; Waldemar A Carlo Journal: J Pediatr Date: 2020-11-25 Impact factor: 4.406
Authors: Katherine Ann Bell; Lillian G Matthews; Sara Cherkerzian; Anna K Prohl; Simon K Warfield; Terrie E Inder; Shun Onishi; Mandy B Belfort Journal: Arch Dis Child Fetal Neonatal Ed Date: 2022-01-20 Impact factor: 6.643
Authors: Emily M Nagel; Marie Hickey; Levi M Teigen; Adam Kuchnia; Holly Schifsky; Tara Holm; Carrie P Earthman; Ellen Demerath; Sara E Ramel Journal: Nutr Clin Pract Date: 2021-06-08 Impact factor: 3.080
Authors: Ariel A Salas; Maggie Jerome; Amber Finck; Jacqueline Razzaghy; Paula Chandler-Laney; Waldemar A Carlo Journal: Pediatr Res Date: 2021-06-28 Impact factor: 3.953
Authors: Katherine A Bell; Lillian G Matthews; Sara Cherkerzian; Caroline Palmer; Kaitlin Drouin; Hunter L Pepin; Deirdre Ellard; Terrie E Inder; Sara E Ramel; Mandy B Belfort Journal: J Pediatr Date: 2019-07-31 Impact factor: 6.314