Literature DB >> 31050421

Overview of Recent Strategic Advances in Medicinal Chemistry.

Gaochan Wu1, Tong Zhao1, Dongwei Kang1, Jian Zhang1, Yuning Song2, Vigneshwaran Namasivayam3, Jacob Kongsted4, Christophe Pannecouque5, Erik De Clercq5, Vasanthanathan Poongavanam4, Xinyong Liu1, Peng Zhan1.   

Abstract

Introducing novel strategies, concepts, and technologies that speed up drug discovery and the drug development cycle is of great importance both in the highly competitive pharmaceutical industry as well as in academia. This Perspective aims to present a "big-picture" overview of recent strategic innovations in medicinal chemistry and drug discovery.

Mesh：

Year:  2019        PMID： 31050421     DOI： 10.1021/acs.jmedchem.9b00359

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  16 in total

1.  Medicinal Chemistry: From Targets to Therapies.

Authors:  Bruce E Maryanoff; Peter Wipf
Journal:  ACS Med Chem Lett       Date:  2019-07-11       Impact factor: 4.345

2.  Synthesis and evaluation of antitumor activity of dibenzodiazepine derivatives.

Authors:  Ke Cao; Jianwei Yan; Fulin Yan; Tiantian Yin
Journal:  Mol Divers       Date:  2020-02-19       Impact factor: 2.943

Review 3.  Teaching an old dog new tricks: Drug discovery by repositioning natural products and their derivatives.

Authors:  Boshi Huang; Yan Zhang
Journal:  Drug Discov Today       Date:  2022-02-16       Impact factor: 8.369

4.  Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer.

Authors:  Matthew W Boudreau; Michael P Mulligan; David J Shapiro; Timothy M Fan; Paul J Hergenrother
Journal:  J Med Chem       Date:  2022-01-26       Impact factor: 8.039

5.  The increasing impact of Chinese innovative drug research on the global stage with a focus on drug discovery.

Authors:  Wei Luo; Cherukupalli Srinivasulu; Xia Hao; Xinyong Liu; Peng Zhan
Journal:  Expert Opin Drug Discov       Date:  2020-06-17       Impact factor: 6.098

6.  Metal binding 6-arylthio-3-hydroxypyrimidine-2,4-diones inhibited human cytomegalovirus by targeting the pUL89 endonuclease of the terminase complex.

Authors:  Lei Wang; Tiffany C Edwards; Rajkumar Lalji Sahani; Jiashu Xie; Hideki Aihara; Robert J Geraghty; Zhengqiang Wang
Journal:  Eur J Med Chem       Date:  2021-06-12       Impact factor: 7.088

Review 7.  Allosteric GABAA Receptor Modulators-A Review on the Most Recent Heterocyclic Chemotypes and Their Synthetic Accessibility.

Authors:  Blanca Angelica Vega Alanis; Maria Teresa Iorio; Luca L Silva; Konstantina Bampali; Margot Ernst; Michael Schnürch; Marko D Mihovilovic
Journal:  Molecules       Date:  2020-02-24       Impact factor: 4.927

8.  Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6.

Authors:  Jean Jacques Vanden Eynde; Arduino A Mangoni; Jarkko Rautio; Jérôme Leprince; Yasu-Taka Azuma; Alfonso T García-Sosa; Christopher Hulme; Josef Jampilek; Rafik Karaman; Wei Li; Paula A C Gomes; Dimitra Hadjipavlou-Litina; Raffaele Capasso; Athina Geronikaki; Laura Cerchia; Jean-Marc Sabatier; Rino Ragno; Tiziano Tuccinardi; Andrea Trabocchi; Jean-Yves Winum; F Javier Luque; Katalin Prokai-Tatrai; Mariana Spetea; Michael Gütschow; Ivan Kosalec; Catherine Guillou; M Helena Vasconcelos; George Kokotos; Giulio Rastelli; Maria Emília de Sousa; Clementina Manera; Sandra Gemma; Stefano Mangani; Carlo Siciliano; Stefania Galdiero; Hong Liu; Peter J H Scott; Cristóbal de Los Ríos; Luigi A Agrofoglio; Simona Collina; Rita C Guedes; Diego Muñoz-Torrero
Journal:  Molecules       Date:  2019-12-28       Impact factor: 4.411

9.  Computational Study on the Mechanism of the Photouncaging Reaction of Vemurafenib: Toward an Enhanced Photoprotection Approach for Photosensitive Drugs.

Authors:  Abdulilah Dawoud Bani-Yaseen
Journal:  Molecules       Date:  2021-03-25       Impact factor: 4.411

10.  Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors.

Authors:  Xiangyi Jiang; Gaochan Wu; Waleed A Zalloum; Megan E Meuser; Alexej Dick; Lin Sun; Chin-Ho Chen; Dongwei Kang; Lanlan Jing; Ruifang Jia; Simon Cocklin; Kuo-Hsiung Lee; Xinyong Liu; Peng Zhan
Journal:  RSC Adv       Date:  2019-09-16       Impact factor: 4.036
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