| Literature DB >> 31039390 |
Lilong Zhang1, Yuqi Hu1, Yao Xu1, Pengfei Li1, Hong Ma1, Xia Li2, Ming Li3.
Abstract
The pathogenesis and development of ankylosing spondylitis (AS) is concealed and complicated. In recent years, alterations in gut microbiota of AS patients have been largely investigated, although the underlying mechanisms remain unclear. This article reviews the recent studies on changes of gut microbiota in AS patients, and discusses the possible correlation between intestinal dysbiosis and AS development from aspects including genetic factor HLA-B27, mucosal immune responses and the depression accompanying AS.Entities:
Keywords: Ankylosing spondylitis; Gut microbiota; Intestinal dysbiosis; Pathogenesis
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Year: 2019 PMID： 31039390 DOI： 10.1016/j.micpath.2019.04.038
Source DB: PubMed Journal: Microb Pathog ISSN： 0882-4010 Impact factor: 3.738