| Literature DB >> 31039329 |
Johanna B Withers1,2, Vanessa Mondol1, Paulina Pawlica1, Nicolle A Rosa-Mercado1, Kazimierz T Tycowski1,2, Salehe Ghasempur1, Seyed F Torabi1, Joan A Steitz1,2.
Abstract
Like their host cells, many viruses express noncoding RNAs (ncRNAs). Despite the technical challenge of ascribing function to ncRNAs, diverse biological roles for virally expressed ncRNAs have been described, including regulation of viral replication, modulation of host gene expression, host immune evasion, cellular survival, and cellular transformation. Insights into conserved interactions between viral ncRNAs and host cell machinery frequently lead to novel findings concerning host cell biology. In this review, we discuss the functions and biogenesis of ncRNAs produced by animal viruses. Specifically, we describe noncanonical pathways of microRNA (miRNA) biogenesis and novel mechanisms used by viruses to manipulate miRNA and messenger RNA stability. We also highlight recent advances in understanding the function of viral long ncRNAs and circular RNAs.Entities:
Keywords: noncoding RNA; virus-host interactions; viruses
Mesh：
Substances：
Year: 2019 PMID： 31039329 PMCID： PMC6768742 DOI： 10.1146/annurev-virology-092818-015811
Source DB: PubMed Journal: Annu Rev Virol ISSN： 2327-056X Impact factor: 10.431