Literature DB >> 31038495

The lipid phase preference of the adenosine A2A receptor depends on its ligand binding state.

M Gertrude Gutierrez1, Jacob Deyell, Kate L White, Lucia C Dalle Ore, Vadim Cherezov, Raymond C Stevens, Noah Malmstadt.   

Abstract

Giant unilamellar protein vesicles (GUPs) were formed with the adenosine A2A receptor (A2AR) incorporated in the lipid bilayer and protein partitioning into the liquid ordered and liquid disordered phases was observed. When no ligand is bound, A2AR partitions preferentially into the liquid disordered phase of GUPs, while ligand-bound A2AR partitions into the liquid ordered phase.

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Year:  2019        PMID： 31038495      PMCID： PMC6561478          DOI： 10.1039/c8cc10130b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  27 in total

Review 1.  Cardiac myocyte adenosine receptors and caveolae.

Authors:  R D Lasley; E J Smart
Journal:  Trends Cardiovasc Med       Date:  2001-10       Impact factor: 6.677

2.  High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.

Authors:  Vadim Cherezov; Daniel M Rosenbaum; Michael A Hanson; Søren G F Rasmussen; Foon Sun Thian; Tong Sun Kobilka; Hee-Jung Choi; Peter Kuhn; William I Weis; Brian K Kobilka; Raymond C Stevens
Journal:  Science       Date:  2007-10-25       Impact factor: 47.728

Review 3.  Lipids, lipid rafts and caveolae: their importance for GPCR signaling and their centrality to the endocannabinoid system.

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Journal:  Life Sci       Date:  2005-08-19       Impact factor: 5.037

Review 4.  Lipid-protein interactions in GPCR-associated signaling.

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Journal:  Biochim Biophys Acta       Date:  2006-09-16

5.  Effect of adenosine A2A receptor activation in murine models of respiratory disorders.

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6.  Miscibility phase diagrams of giant vesicles containing sphingomyelin.

Authors:  Sarah L Veatch; Sarah L Keller
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7.  Lipid rafts reconstituted in model membranes.

Authors:  C Dietrich; L A Bagatolli; Z N Volovyk; N L Thompson; M Levi; K Jacobson; E Gratton
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8.  The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.

Authors:  Veli-Pekka Jaakola; Mark T Griffith; Michael A Hanson; Vadim Cherezov; Ellen Y T Chien; J Robert Lane; Adriaan P Ijzerman; Raymond C Stevens
Journal:  Science       Date:  2008-10-02       Impact factor: 47.728

9.  Separation of liquid phases in giant vesicles of ternary mixtures of phospholipids and cholesterol.

Authors:  Sarah L Veatch; Sarah L Keller
Journal:  Biophys J       Date:  2003-11       Impact factor: 4.033

10.  Localization of the mouse 5-hydroxytryptamine(1A) receptor in lipid microdomains depends on its palmitoylation and is involved in receptor-mediated signaling.

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Journal:  Mol Pharmacol       Date:  2007-05-31       Impact factor: 4.436
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2.  Local Enrichment of Unsaturated Chains around the A2A Adenosine Receptor.

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Journal:  Biochemistry       Date:  2019-09-19       Impact factor: 3.162

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Authors:  Alison N Leonard; Edward Lyman
Journal:  Biophys J       Date:  2021-02-26       Impact factor: 4.033

4.  Allosteric modulation of the adenosine A2A receptor by cholesterol.

Authors:  Shuya Kate Huang; Omar Almurad; Reizel J Pejana; Zachary A Morrison; Aditya Pandey; Louis-Philippe Picard; Mark Nitz; Adnan Sljoka; R Scott Prosser
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5.  The Role of Lipids in Allosteric Modulation of Dopamine D2 Receptor-In Silico Study.

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  5 in total

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