Literature DB >> 31036689

Nitroglycerin-Citrate-Ethanol Catheter Lock Solution Is Highly Effective for In Vitro Eradication of Candida auris Biofilm.

Nylev Vargas-Cruz1, Ruth A Reitzel2, Joel Rosenblatt1, Anne-Marie Chaftari1, Rita Wilson Dib1, Ray Hachem1, Dimitrios P Kontoyiannis1, Issam I Raad1.   

Abstract

Candida auris poses emerging risks for causing severe central line-associated bloodstream infections. We tested in vitro the ability of antifungal lock solutions to rapidly eradicate C. auris biofilms. Liposomal amphotericin B, amphotericin B deoxycholate, fluconazole, voriconazole, micafungin, caspofungin, and anidulafungin failed to completely eradicate all 10 tested C. auris biofilms. Conversely, nitroglycerin-citrate-ethanol (NiCE) catheter lock solution completely eradicated all replicates for all of C. auris biofilms tested.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  Candida auriszzm321990; biofilm; catheter lock solution; nitroglycerin-citrate-ethanol

Year:  2019        PMID： 31036689      PMCID： PMC6591641          DOI： 10.1128/AAC.00299-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

1.  National Nosocomial Infections Surveillance (NNIS) System Report, Data Summary from January 1990-May 1999, issued June 1999. A report from the NNIS System.

Authors: 
Journal:  Am J Infect Control       Date:  1999-12       Impact factor: 2.918

Review 2.  Candida auris: a Review of the Literature.

Authors:  Anna Jeffery-Smith; Surabhi K Taori; Silke Schelenz; Katie Jeffery; Elizabeth M Johnson; Andrew Borman; Rohini Manuel; Colin S Brown
Journal:  Clin Microbiol Rev       Date:  2017-11-15       Impact factor: 26.132

Review 3.  The Candida auris Alert: Facts and Perspectives.

Authors:  Frederic Lamoth; Dimitrios P Kontoyiannis
Journal:  J Infect Dis       Date:  2018-01-30       Impact factor: 5.226

4.  Ultrastructural analysis of indwelling vascular catheters: a quantitative relationship between luminal colonization and duration of placement.

Authors:  I Raad; W Costerton; U Sabharwal; M Sacilowski; E Anaissie; G P Bodey
Journal:  J Infect Dis       Date:  1993-08       Impact factor: 5.226

5.  Antifungal susceptibility of Candida biofilms: unique efficacy of amphotericin B lipid formulations and echinocandins.

Authors:  D M Kuhn; T George; J Chandra; P K Mukherjee; M A Ghannoum
Journal:  Antimicrob Agents Chemother       Date:  2002-06       Impact factor: 5.191

6.  Impact of high-dose granulocyte transfusions in patients with cancer with candidemia: retrospective case-control analysis of 491 episodes of Candida species bloodstream infections.

Authors:  Amar Safdar; Hend A Hanna; Maha Boktour; Dimitrios P Kontoyiannis; Ray Hachem; Benjamin Lichtiger; Emil J Freireich; Issam I Raad
Journal:  Cancer       Date:  2004-12-15       Impact factor: 6.860

7.  A Novel Nonantibiotic Nitroglycerin-Based Catheter Lock Solution for Prevention of Intraluminal Central Venous Catheter Infections in Cancer Patients.

Authors:  Anne-Marie Chaftari; Ray Hachem; Ariel Szvalb; Mahnaz Taremi; Bruno Granwehr; George Michael Viola; Sapna Amin; Andrew Assaf; Yazan Numan; Pankil Shah; Ketevan Gasitashvili; Elizabeth Natividad; Ying Jiang; Rebecca Slack; Ruth Reitzel; Joel Rosenblatt; Elie Mouhayar; Issam Raad
Journal:  Antimicrob Agents Chemother       Date:  2017-06-27       Impact factor: 5.191

8.  Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010.

Authors:  Dawn M Sievert; Philip Ricks; Jonathan R Edwards; Amy Schneider; Jean Patel; Arjun Srinivasan; Alex Kallen; Brandi Limbago; Scott Fridkin
Journal:  Infect Control Hosp Epidemiol       Date:  2012-11-27       Impact factor: 3.254

9.  Mechanism of fluconazole resistance in Candida albicans biofilms: phase-specific role of efflux pumps and membrane sterols.

Authors:  Pranab K Mukherjee; Jyotsna Chandra; Duncan M Kuhn; Mahmoud A Ghannoum
Journal:  Infect Immun       Date:  2003-08       Impact factor: 3.441

10.  Transcriptome Assembly and Profiling of Candida auris Reveals Novel Insights into Biofilm-Mediated Resistance.

Authors:  Ryan Kean; Christopher Delaney; Leighann Sherry; Andrew Borman; Elizabeth M Johnson; Malcolm D Richardson; Riina Rautemaa-Richardson; Craig Williams; Gordon Ramage
Journal:  mSphere       Date:  2018-07-11       Impact factor: 4.389
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  3 in total

1.  In vitro and in vivo interaction of caspofungin with isavuconazole against Candida auris planktonic cells and biofilms.

Authors:  Fruzsina Nagy; Zoltán Tóth; Fanni Nyikos; Lajos Forgács; Ágnes Jakab; Andrew M Borman; László Majoros; Renátó Kovács
Journal:  Med Mycol       Date:  2021-10-04       Impact factor: 4.076

Review 2.  Antifungal lock therapy: an eternal promise or an effective alternative therapeutic approach?

Authors:  R Kovács; L Majoros
Journal:  Lett Appl Microbiol       Date:  2022-01-30       Impact factor: 2.813

3.  NO Candida auris: Nitric Oxide in Nanotherapeutics to Combat Emerging Fungal Pathogen Candida auris.

Authors:  Levi G Cleare; Kevin L Li; Waleed M Abuzeid; Parimala Nacharaju; Joel M Friedman; Joshua D Nosanchuk
Journal:  J Fungi (Basel)       Date:  2020-06-12
  3 in total

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